ERBB2 Antibody – Rabbit Polyclonal

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Cabodi, S., et al. FASEB J. 24(10):3796-3808(2010). Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010). Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010). Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010). Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010).

Small volumes of anti-ERBB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6296341 is an antibody targeting ERBB2. Also known as ERBB2, Phosphorylated (Y1140) (Erbb2, Kiaa3023, Neu, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340) (FITC). Reactive in Mouse. Host: Rabbit.