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GLRB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6302620

This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
GLRB, Polyclonal Antibody
Full Product Name
GLRB, NT (GLRB, Glycine receptor subunit beta, Glycine receptor 58kD subunit) (MaxLight 750)
Product Gene Name
anti-GLRB antibody
Product Synonym Names
GLRB; Glycine receptor subunit beta; Glycine receptor 58kD subunit
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
56,122 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (157997277..158093251). Location: 4q31.3
OMIM
138492
3D Structure
ModBase 3D Structure for P48167
Immunogen
GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-132 amino acids from the N-terminal region of human GLRB.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-GLRB antibody

Antibodies; Receptors
Applications Tested/Suitable for anti-GLRB antibody
Western Blot (WB), FLISA
Application Notes for anti-GLRB antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GLRB antibody

Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010). Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009): Ziegler, E., et al. Naunyn Schmiedebergs Arch. Pharmacol. 380(4):277-291(2009). Tabakoff, B., et al. BMC Biol. 7, 70 (2009): Ahrens, J., et al. Pharmacology 83(4):217-222(2009).

Other Notes

Small volumes of anti-GLRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLRB purchase

MBS6302620 is an antibody targeting GLRB. Also known as GLRB, NT (GLRB, Glycine receptor subunit beta, Glycine receptor 58kD subunit) (MaxLight 750). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRB. It may not necessarily be applicable to this product.

NCBI GI #
260593684
NCBI GeneID
2743
NCBI Accession #
NP_001159532.1
NCBI Related Accession #
NP_000815.1
UniProt Primary Accession #
P48167
UniProt Secondary Accession #
A8K3K2; D3DP23; F5GWE1
UniProt Related Accession #
P48167
GenBank Nucleotide #
NM_001166060.1
NCBI Official Full Name
glycine receptor subunit beta isoform A
NCBI Official Synonym Full Names
glycine receptor, beta
NCBI Official Symbol
GLRB
NCBI Official Synonym Symbols
HKPX2
UniProt Protein Name
Glycine receptor subunit beta
UniProt Synonym Protein Names
Glycine receptor 58 kDa subunit
Protein Family
Glycine receptor
UniProt Gene Name
GLRB
UniProt Entry Name
GLRB_HUMAN
NCBI Protein Information
glycine receptor subunit beta; glycine receptor, beta subunit; glycine receptor 58 kDa subunit

UniProt Comments for GLRB

GLRB: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRB are the cause of hyperekplexia type 2 (HKPX2). HKPX2 is a neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile2 stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub- subfamily.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: protein binding; extracellular-glycine-gated chloride channel activity; glycine binding; extracellular-glycine-gated ion channel activity; drug binding

Biological Process: nervous system development; startle response; synaptic transmission, glycinergic; righting reflex; protein heterooligomerization; acrosome reaction; adult walking behavior; synaptic transmission; regulation of membrane potential; visual perception; neuropeptide signaling pathway; ion transport; transmembrane transport

Disease: Hyperekplexia 2
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLRB antibody

 Reference Product  PubMed Publications
 GLRA1 antibody  >26 publications with GLRB and GLRA1
 SLC6A5 antibody  >12 publications with GLRB and SLC6A5
 ARHGEF9 antibody  >8 publications with GLRB and ARHGEF9
 GLRA2 antibody  >8 publications with GLRB and GLRA2
 GPHN antibody  >6 publications with GLRB and GPHN
 GLRA3 antibody  >4 publications with GLRB and GLRA3
 AMPH antibody  >1 publications with GLRB and AMPH

Pathways associated with anti-GLRB antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-GLRB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with GLRB and Nervous System Diseases
 Brain Diseases Antibodies  >6 publications with GLRB and Brain Diseases
 Inflammation Antibodies  >2 publications with GLRB and Inflammation
 Hyperexplexia hereditary Antibodies  >2 publications with GLRB and Hyperexplexia hereditary
 Cleft Palate Antibodies  >1 publications with GLRB and Cleft Palate
 Movement Disorders Antibodies  >1 publications with GLRB and Movement Disorders
 Learning Disorders Antibodies  >1 publications with GLRB and Learning Disorders
 Neoplasms Antibodies  >1 publications with GLRB and Neoplasms
 Memory Disorders Antibodies  >1 publications with GLRB and Memory Disorders

Organs/Tissues associated with anti-GLRB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with GLRB and Brain
 Muscle Antibodies  >14 publications with GLRB and Muscle
 Kidney Antibodies  >10 publications with GLRB and Kidney
 Nerve Antibodies  >4 publications with GLRB and Nerve
 Eye Antibodies  >4 publications with GLRB and Eye
 Liver Antibodies  >3 publications with GLRB and Liver
 Ovary Antibodies  >1 publications with GLRB and Ovary
 Testis Antibodies  >1 publications with GLRB and Testis
 Heart Antibodies  >1 publications with GLRB and Heart
 Lung Antibodies  >1 publications with GLRB and Lung
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