Hexokinase, Pan (HKL3) Antibody – Rabbit Polyclonal

Hexokinase catalyzes the first step of several metabolic pathways by converting D-hexose to D-hexose-6-P. Hexokinase is an allosteric enzyme inhibited by its products glucose-6-phosphate. At least 4 related hexokinase isoforms (HXKI-III; HXK-IV also known as Glucokinase) have been cloned and characterized. Hexokinases (~100kD for HXK1-III; HXKIV lacks the N-terminal domains and is ~50kD) are outer mitochondrial membrane proteins. The N- terminus, containing the mitochondrial target sequence, and the C- terminal has high sequence homology among various isoforms. The catalytic activity is associated with the C-terminus and other regulatory functions are controlled by the N-terminus. HXK1 is located on chromosome 10. It exists either as a cytosolic protein or as a protein associated with the outer mitochondrial membrane via an interaction with porin, a voltage-dependent anion channel. HXK1/HK1 is alternatively spliced into 3 isoforms: HK1-SA (975aa) and HK1-SB and HK1-SC are alternatively spliced at Met-1 and Met- 53. Isoform HK1-SA (1-974aa), isoform HK1-SB and isoform HK1- SC (53-974aa) are found only in spermatogenic cells. Isoform HK1- SC is detected in round spermatids, condensing spermatids and mature sperm where it is found in the head membranes, mitochondria of the midpiece and the fibrous sheath of the flagellum. Defects in HK1 gene causes hemolytic anemia.

Small volumes of anti-HKL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS629386 is an antibody targeting HKL3. Also known as Anti-Hexokinase, Pan (HXK1, HXK2, HXK3). Reactive in Mouse. Host: Rabbit.