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HSD17B7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8571783

HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed… More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HSD17B7, Polyclonal Antibody
Full Product Name
HSD17B7 Polyclonal Antibody
Product Gene Name
anti-HSD17B7 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
34kDa; 37kDa; 38kDa
OMIM
606756
3D Structure
ModBase 3D Structure for P56937
Immunogen
Recombinant protein of human HSD17B7.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-HSD17B7 antibody
Western Blot (WB)
Application Notes for anti-HSD17B7 antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-HSD17B7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSD17B7 purchase

MBS8571783 is an antibody targeting HSD17B7. Also known as HSD17B7 Polyclonal Antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B7. It may not necessarily be applicable to this product.

NCBI GI #
37183042
NCBI GeneID
51478
NCBI Accession #
AAQ89321.1
UniProt Primary Accession #
P56937
UniProt Related Accession #
P56937
NCBI Official Full Name
HSD17B7
NCBI Official Synonym Full Names
hydroxysteroid 17-beta dehydrogenase 7
NCBI Official Symbol
HSD17B7
NCBI Official Synonym Symbols
PRAP; SDR37C1
UniProt Protein Name
3-keto-steroid reductase
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7
UniProt Gene Name
HSD17B7
UniProt Synonym Gene Names
17-beta-HSD 7
UniProt Entry Name
DHB7_HUMAN
NCBI Protein Information
3-keto-steroid reductase

UniProt Comments for HSD17B7

Function: Responsible for the reduction of the keto group on the C-3 of sterols. Ref.11

Catalytic activity: A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathway: Steroid biosynthesis; estrogen biosynthesis.Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.

Subcellular location: Cell membrane; Single-pass membrane protein.

Tissue specificity: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.

Post-translational modification: Phosphorylated.

Sequence similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
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Research Articles on HSD17B7

1. Substrate affinity of 17beta-hydroxysteroid dehydrogenase type 7 toward estrone and 5alpha-dihydrotestosterone are similar.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSD17B7 antibody

 Reference Product  PubMed Publications
 HSD17B1 antibody  >6 publications with HSD17B7 and HSD17B1
 SQLE antibody  >2 publications with HSD17B7 and SQLE
 SC4MOL antibody  >1 publications with HSD17B7 and SC4MOL
 PRLR antibody  >1 publications with HSD17B7 and PRLR

Pathways associated with anti-HSD17B7 antibody

 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram

Diseases associated with anti-HSD17B7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with HSD17B7 and Neoplasms
 Breast Neoplasms Antibodies  >5 publications with HSD17B7 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with HSD17B7 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSD17B7 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with HSD17B7 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with HSD17B7 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with HSD17B7 and Neoplasms, Experimental
 Mammary Neoplasms, Animal Antibodies  >1 publications with HSD17B7 and Mammary Neoplasms, Animal
 Edema Antibodies  >1 publications with HSD17B7 and Edema
 Ovarian Diseases Antibodies  >1 publications with HSD17B7 and Ovarian Diseases

Organs/Tissues associated with anti-HSD17B7 antibody

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >6 publications with HSD17B7 and Ovary
 Liver Antibodies  >5 publications with HSD17B7 and Liver
 Blood Antibodies  >5 publications with HSD17B7 and Blood
 Brain Antibodies  >4 publications with HSD17B7 and Brain
 Mammary Gland Antibodies  >3 publications with HSD17B7 and Mammary Gland
 Embryonic Tissue Antibodies  >3 publications with HSD17B7 and Embryonic Tissue
 Heart Antibodies  >3 publications with HSD17B7 and Heart
 Testis Antibodies  >2 publications with HSD17B7 and Testis
 Placenta Antibodies  >2 publications with HSD17B7 and Placenta
 Prostate Antibodies  >1 publications with HSD17B7 and Prostate
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