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SLC12A7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618917

Chloride is a critical component of all living cells. It is also the single most dominant diffusible anion inside of most cells-the others are mostly impermeable organic anions. Since cytoplasmic electroneutrality is maintained under normal physiological… More details

$965 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KCC4 (SLC12A7), Polyclonal Antibody
Full Product Name
KCC4 (K, Cl Cotransporter 4)
Product Gene Name
anti-SLC12A7 antibody
Product Synonym Names
Anti -KCC4 (K, Cl Cotransporter 4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in 100mM Tris, pH 7.5, 0.02% BSA, 0.05% sodium azide, 40% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes KCC4 (K, Cl Cotransporter 4). Species Sequence Homology
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
119,106 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (1050489..1112172, complement). Location: 5p15
OMIM
604879
3D Structure
ModBase 3D Structure for Q9Y666
Immunogen
A 16aa peptide sequence within the cytoplasmic, N-terminus of mouse KCC4 (KLH coupled)

Product Categories/Family for anti-SLC12A7 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SLC12A7 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SLC12A7 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique.
ELISA: 1:10,000-1:100,000. Use 50-100ng of control peptide/well.

Other Notes

Small volumes of anti-SLC12A7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC12A7 purchase

MBS618917 is an antibody targeting SLC12A7. Also known as KCC4 (K, Cl Cotransporter 4). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC12A7. It may not necessarily be applicable to this product.

NCBI GI #
5106521
NCBI GeneID
10723
UniProt Primary Accession #
Q9Y666
UniProt Secondary Accession #
Q4G0F3; Q96I81; Q9H7I3; Q9H7I7; Q9UFW2; A6NDS8
UniProt Related Accession #
Q9Y666
NCBI Official Full Name
K-Cl cotransporter KCC4
NCBI Official Synonym Full Names
solute carrier family 12 (potassium/chloride transporters), member 7
NCBI Official Symbol
SLC12A7
NCBI Official Synonym Symbols
KCC4; DKFZp434F076
UniProt Protein Name
Solute carrier family 12 member 7
UniProt Synonym Protein Names
Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4
Protein Family
Solute carrier family
UniProt Gene Name
SLC12A7
UniProt Synonym Gene Names
KCC4
UniProt Entry Name
S12A7_HUMAN
NCBI Protein Information
solute carrier family 12 member 7; OTTHUMP00000220873; K-Cl cotransporter 4; potassium/chloride transporter KCC4; electroneutral potassium-chloride cotransporter 4

UniProt Comments for SLC12A7

KCC4: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. Belongs to the SLC12A transporter family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein kinase binding; potassium:chloride symporter activity

Biological Process: transport; ion transport; cell volume homeostasis; transmembrane transport; potassium ion transport
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Research Articles on SLC12A7

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC12A7 antibody

 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC12A7 antibody

 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >4 publications with SLC12A7 and Female Urogenital Diseases
 Neoplasms Antibodies  >3 publications with SLC12A7 and Neoplasms
 Uterine Cervical Neoplasms Antibodies  >2 publications with SLC12A7 and Uterine Cervical Neoplasms
 Uterine Neoplasms Antibodies  >2 publications with SLC12A7 and Uterine Neoplasms
 Gonadal Disorders Antibodies  >2 publications with SLC12A7 and Gonadal Disorders
 Genital Neoplasms, Female Antibodies  >2 publications with SLC12A7 and Genital Neoplasms, Female
 Uterine Diseases Antibodies  >2 publications with SLC12A7 and Uterine Diseases
 Male Urogenital Diseases Antibodies  >2 publications with SLC12A7 and Male Urogenital Diseases
 Kidney Diseases Antibodies  >2 publications with SLC12A7 and Kidney Diseases
 Hearing Loss Antibodies  >1 publications with SLC12A7 and Hearing Loss

Organs/Tissues associated with anti-SLC12A7 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >10 publications with SLC12A7 and Kidney
 Brain Antibodies  >7 publications with SLC12A7 and Brain
 Muscle Antibodies  >3 publications with SLC12A7 and Muscle
 Stomach Antibodies  >2 publications with SLC12A7 and Stomach
 Lung Antibodies  >2 publications with SLC12A7 and Lung
 Liver Antibodies  >1 publications with SLC12A7 and Liver
 Heart Antibodies  >1 publications with SLC12A7 and Heart
 Testis Antibodies  >1 publications with SLC12A7 and Testis
 Pancreas Antibodies  >1 publications with SLC12A7 and Pancreas
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