• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

LARS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642429

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LARS, Polyclonal Antibody
Full Product Name
LARS, NT (LARS, KIAA1352, Leucine-tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase)
Product Gene Name
anti-LARS antibody
Product Synonym Names
Anti -LARS, NT (LARS, KIAA1352, Leucine-tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
134,466 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (145492589..145562294, complement). Location: 5q32
OMIM
151350
3D Structure
ModBase 3D Structure for Q9P2J5
Immunogen
LARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-213 amino acids from the N-terminal region of human LARS.

Product Categories/Family for anti-LARS antibody

Antibodies; Abs to KIAA; orf
Applications Tested/Suitable for anti-LARS antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-LARS antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Flow Cytometry: 1:10-50

Flow Cytometry (FC/FACS) of anti-LARS antibody

LARS Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-LARS Polyclonal Antibody – Cat# MBS642429

Western Blot (WB) of anti-LARS antibody

LARS Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the LARS antibody detected the LARS protein (arrow).
Rabbit Anti-LARS Polyclonal Antibody, Western Blot (WB) – Cat# MBS642429

Other Notes

Small volumes of anti-LARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LARS purchase

MBS642429 is an antibody targeting LARS. Also known as LARS, NT (LARS, KIAA1352, Leucine-tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LARS. It may not necessarily be applicable to this product.

NCBI GI #
108773810
NCBI GeneID
51520
NCBI Accession #
NP_064502.9
UniProt Primary Accession #
Q9P2J5
UniProt Secondary Accession #
Q9NSE1; A7E266
UniProt Related Accession #
Q9P2J5
GenBank Nucleotide #
NM_020117.9
NCBI Official Full Name
leucine--tRNA ligase, cytoplasmic
NCBI Official Synonym Full Names
leucyl-tRNA synthetase
NCBI Official Symbol
LARS
NCBI Official Synonym Symbols
LRS; LEUS; LARS1; LEURS; PIG44; RNTLS; HSPC192; hr025Cl
UniProt Protein Name
Leucine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Leucyl-tRNA synthetase
Protein Family
Leucine--tRNA ligase
UniProt Gene Name
LARS
UniProt Synonym Gene Names
KIAA1352; LeuRS
UniProt Entry Name
SYLC_HUMAN
NCBI Protein Information
leucine--tRNA ligase, cytoplasmic; leucine translase; leucine-tRNA ligase; proliferation-inducing gene 44; cytosolic leucyl-tRNA synthetase; cytoplasmic leucyl-tRNA synthetase; leucine tRNA ligase 1, cytoplasmic; leucyl-tRNA synthetase, cytoplasmic

UniProt Comments for LARS

LARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family.

Protein type: Translation; EC 6.1.1.4; Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: methionine-tRNA ligase activity; leucine-tRNA ligase activity; protein binding; ATP binding

Biological Process: leucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; regulation of translational fidelity; methionyl-tRNA aminoacylation; gene expression

Disease: Infantile Liver Failure Syndrome 1
Show more

Research Articles on LARS

1. Identification of a mutation in LARS as a novel cause of infantile hepatopathy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LARS antibody

 Reference Product  PubMed Publications
 WARS antibody  >7 publications with LARS and WARS
 MARS antibody  >7 publications with LARS and MARS
 IARS antibody  >4 publications with LARS and IARS
 SARS antibody  >2 publications with LARS and SARS
 YARS antibody  >1 publications with LARS and YARS
 RARS antibody  >1 publications with LARS and RARS

Pathways associated with anti-LARS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-LARS antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >382 publications with LARS and Cardiovascular Diseases
 Neoplasms Antibodies  >312 publications with LARS and Neoplasms
 Brain Diseases Antibodies  >282 publications with LARS and Brain Diseases
 Immune System Diseases Antibodies  >216 publications with LARS and Immune System Diseases
 Heart Diseases Antibodies  >188 publications with LARS and Heart Diseases
 Musculoskeletal Diseases Antibodies  >174 publications with LARS and Musculoskeletal Diseases
 Inflammation Antibodies  >107 publications with LARS and Inflammation
 Liver Diseases Antibodies  >54 publications with LARS and Liver Diseases
 Hemorrhage Antibodies  >51 publications with LARS and Hemorrhage
 Kidney Diseases Antibodies  >40 publications with LARS and Kidney Diseases

Organs/Tissues associated with anti-LARS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >547 publications with LARS and Blood
 Brain Antibodies  >278 publications with LARS and Brain
 Vascular Antibodies  >207 publications with LARS and Vascular
 Heart Antibodies  >175 publications with LARS and Heart
 Bone Antibodies  >172 publications with LARS and Bone
 Nerve Antibodies  >111 publications with LARS and Nerve
 Muscle Antibodies  >97 publications with LARS and Muscle
 Liver Antibodies  >91 publications with LARS and Liver
 Lung Antibodies  >85 publications with LARS and Lung
 Skin Antibodies  >82 publications with LARS and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000