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LIPE Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8570365

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LIPE, Polyclonal Antibody
Full Product Name
LIPE Polyclonal Antibody
Product Gene Name
anti-LIPE antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
84kDa; 116kDa
OMIM
151750
3D Structure
ModBase 3D Structure for Q05469
Immunogen
A synthetic peptide of human LIPE (NP_005348.2).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LIPE antibody
Western Blot (WB)
Application Notes for anti-LIPE antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-LIPE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LIPE purchase

MBS8570365 is an antibody targeting LIPE. Also known as LIPE Polyclonal Antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LIPE. It may not necessarily be applicable to this product.

NCBI GI #
21328446
NCBI GeneID
3991
NCBI Accession #
NP_005348.2
UniProt Primary Accession #
Q05469
UniProt Related Accession #
Q05469
GenBank Nucleotide #
NP_005348.2
NCBI Official Full Name
hormone-sensitive lipase
NCBI Official Synonym Full Names
lipase E, hormone sensitive type
NCBI Official Symbol
LIPE
NCBI Official Synonym Symbols
HSL; LHS; AOMS4; FPLD6
UniProt Protein Name
Hormone-sensitive lipase
Protein Family
Hormone-sensitive lipase
UniProt Gene Name
LIPE
UniProt Synonym Gene Names
HSL
UniProt Entry Name
LIPS_HUMAN
NCBI Protein Information
hormone-sensitive lipase

UniProt Comments for LIPE

HSL: hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.

Protein type: EC 3.1.1.79; Lipase

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: lipid particle; caveola; cytosol

Molecular Function: triacylglycerol lipase activity; hormone-sensitive lipase activity; protein binding; protein kinase binding

Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process

Disease: Abdominal Obesity-metabolic Syndrome 4
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Research Articles on LIPE

1. The homozygous null LIPE mutation could result in marked inhibition of lipolysis from some adipose tissue depots and thus may induce an extremely rare phenotype of MSL and partial lipodystrophy in adulthood associated with complications of insulin resistance, such as diabetes, hypertriglyceridemia and hepatic steatosis.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LIPE antibody

 Reference Product  PubMed Publications
 FABP4 antibody  >2 publications with LIPE and FABP4
 PRKACA antibody  >1 publications with LIPE and PRKACA

Pathways associated with anti-LIPE antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies  Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-LIPE antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >19 publications with LIPE and Obesity
 Insulin Resistance Antibodies  >11 publications with LIPE and Insulin Resistance
 Cardiovascular Diseases Antibodies  >11 publications with LIPE and Cardiovascular Diseases
 Drug Toxicity Antibodies  >8 publications with LIPE and Drug Toxicity
 Atherosclerosis Antibodies  >6 publications with LIPE and Atherosclerosis
 Muscular Diseases Antibodies  >6 publications with LIPE and Muscular Diseases
 Hypertension Antibodies  >4 publications with LIPE and Hypertension
 Weight Gain Antibodies  >4 publications with LIPE and Weight Gain
 Fatty Liver Antibodies  >3 publications with LIPE and Fatty Liver
 Diabetes Mellitus Antibodies  >3 publications with LIPE and Diabetes Mellitus

Organs/Tissues associated with anti-LIPE antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with LIPE and Blood
 Brain Antibodies  >29 publications with LIPE and Brain
 Adipose Tissue Antibodies  >19 publications with LIPE and Adipose Tissue
 Kidney Antibodies  >6 publications with LIPE and Kidney
 Lung Antibodies  >5 publications with LIPE and Lung
 Placenta Antibodies  >4 publications with LIPE and Placenta
 Embryonic Tissue Antibodies  >4 publications with LIPE and Embryonic Tissue
 Eye Antibodies  >3 publications with LIPE and Eye
 Adrenal Gland Antibodies  >3 publications with LIPE and Adrenal Gland
 Bone Antibodies  >3 publications with LIPE and Bone
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