NPR1 Antibody – Rabbit Polyclonal

ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction.

Protein type: Lyase; Receptor, misc.; Membrane protein, integral; Kinase, protein; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; EC 4.6.1.2; Guanylyl cyclase; RGC group; RGC family

Cellular Component: membrane; plasma membrane; integral to membrane; intracellular; receptor complex

Molecular Function: guanylate cyclase activity; GTP binding; hormone binding; phosphorus-oxygen lyase activity; natriuretic peptide receptor activity; peptide hormone binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; lyase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: cGMP biosynthetic process; cyclic nucleotide biosynthetic process; cell surface receptor linked signal transduction; positive regulation of cGMP biosynthetic process; negative regulation of smooth muscle cell proliferation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of blood vessel size; protein amino acid phosphorylation; dopamine metabolic process