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NTRK3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8552390

MBS8552390 is an antibody targeting NTRK3. Also known as NTRK3 (N-Term) (Mouse) Rabbit pAb. Reactive in Mouse. Host: Rabbit. More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NTRK3, Polyclonal Antibody
Full Product Name
NTRK3 (N-Term) (Mouse) Rabbit pAb
Product Gene Name
anti-NTRK3 antibody
Product Synonym Names
NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; Ntrk3; TrkC
Clonality
Polyclonal
Isotype
Ig
Clone Number
RB34849
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Affinity Purified
3D Structure
ModBase 3D Structure for Q6VNS1
Immunogen
This mouse Ntrk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-188 amino acids from the N-terminal region of mouse Ntrk3.
Cellular Localization
Membrane
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NTRK3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NTRK3 antibody
WB: 1:1000
IHC: 1:10-50

Other Notes

Small volumes of anti-NTRK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NTRK3. It may not necessarily be applicable to this product.

NCBI GI #
33413412
NCBI GeneID
18213
NCBI Accession #
NP_032772.3
UniProt Primary Accession #
Q6VNS1
UniProt Related Accession #
Q6VNS1
GenBank Nucleotide #
NP_032772.3
NCBI Official Full Name
NT-3 growth factor receptor isoform a
NCBI Official Synonym Full Names
neurotrophic tyrosine kinase, receptor, type 3
NCBI Official Symbol
Ntrk3
NCBI Official Synonym Symbols
TrkC; AW125844; Ntrk3_tv3
UniProt Protein Name
NT-3 growth factor receptor
UniProt Synonym Protein Names
GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase
Protein Family
NT-3 growth factor receptor
UniProt Gene Name
Ntrk3
UniProt Synonym Gene Names
TrkC; Trk-C
UniProt Entry Name
NTRK3_MOUSE
NCBI Protein Information
NT-3 growth factor receptor

UniProt Comments for NTRK3

Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1

By similarity.

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads. Ref.2

Post-translational modification: Ligand-mediated auto-phosphorylation

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 protein kinase domain.
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Research Articles on NTRK3

1. TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. This signaling mechanism may be important for TrkC-mediated cytoskeletal dynamics in podocyte disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NTRK3 antibody

 Products by Pathway  Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies  PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with anti-NTRK3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >251 publications with NTRK3 and Neoplasms
 Nervous System Diseases Antibodies  >148 publications with NTRK3 and Nervous System Diseases
 Death Antibodies  >136 publications with NTRK3 and Death
 Central Nervous System Diseases Antibodies  >109 publications with NTRK3 and Central Nervous System Diseases
 Brain Diseases Antibodies  >103 publications with NTRK3 and Brain Diseases
 Disease Models, Animal Antibodies  >45 publications with NTRK3 and Disease Models, Animal
 Nerve Degeneration Antibodies  >37 publications with NTRK3 and Nerve Degeneration
 Breast Neoplasms Antibodies  >34 publications with NTRK3 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >23 publications with NTRK3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >23 publications with NTRK3 and Kidney Diseases

Organs/Tissues associated with anti-NTRK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >673 publications with NTRK3 and Brain
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