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OBFC2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6327511

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by… More details

$1025 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
OBFC2B, Polyclonal Antibody
Full Product Name
OBFC2B, CT (NABP2, OBFC2B, SSB1, SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, Single-stranded DNA-b
Product Gene Name
anti-OBFC2B antibody
Product Synonym Names
NABP2; OBFC2B; SSB1; SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
11,493 Da
OMIM
612104
3D Structure
ModBase 3D Structure for Q9BQ15
Immunogen
OBFC2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-211 amino acids from the C-terminal region of human OBFC2B.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-OBFC2B antibody

Antibodies; Binding Proteins
Applications Tested/Suitable for anti-OBFC2B antibody
Western Blot (WB), FLISA
Application Notes for anti-OBFC2B antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-OBFC2B antibody

Skaar, J.R., et al. J. Cell Biol. 187(1):25-32(2009). Li, Y., et al. J. Biol. Chem. 284(35):23525-23531(2009). Huang, J., et al. Mol. Cell 35(3):384-393(2009). Richard, D.J., et al. Nature 453(7195):677-681(2008). Lamesch, P., et al. Genomics 89(3):307-315(2007).

Other Notes

Small volumes of anti-OBFC2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OBFC2B purchase

MBS6327511 is an antibody targeting OBFC2B. Also known as OBFC2B, CT (NABP2, OBFC2B, SSB1, SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, Single-stranded DNA-b. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OBFC2B. It may not necessarily be applicable to this product.

NCBI GI #
13129048
NCBI GeneID
79035
NCBI Accession #
NP_076973.1
UniProt Primary Accession #
Q9BQ15
UniProt Secondary Accession #
Q6XYC8; A6NDF8
UniProt Related Accession #
Q9BQ15
GenBank Nucleotide #
NM_024068.3
NCBI Official Full Name
SOSS complex subunit B1
NCBI Official Synonym Full Names
nucleic acid binding protein 2
NCBI Official Symbol
NABP2
NCBI Official Synonym Symbols
SSB1; hSSB1; OBFC2B; SOSS-B1
UniProt Protein Name
SOSS complex subunit B1
UniProt Synonym Protein Names
Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1
UniProt Gene Name
NABP2
UniProt Synonym Gene Names
OBFC2B; SSB1; SOSS-B1; hSSB1
UniProt Entry Name
SOSB1_HUMAN
NCBI Protein Information
SOSS complex subunit B1; LP3587; sensor of ssDNA subunit B1; nucleic acid-binding protein 2; single strand DNA-binding protein 1; single-stranded DNA-binding protein 1; sensor of single-strand DNA complex subunit B1; oligonucleotide/oligosaccharide-bindin

UniProt Comments for OBFC2B

OBFC2B: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA repair, damage

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; single-stranded DNA binding

Biological Process: mitotic cell cycle checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OBFC2B antibody

 Reference Product  PubMed Publications
 NABP1 antibody  >2 publications with OBFC2B and NABP1
 INTS3 antibody  >1 publications with OBFC2B and INTS3

Organs/Tissues associated with anti-OBFC2B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with OBFC2B and Blood
 Thyroid Antibodies  >1 publications with OBFC2B and Thyroid
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