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RANK Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178245

Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, ELISA in Mouse.Background: Receptor Activator of Nuclear Factor kappa B (RANK), also known as TRANCE Receptor, is a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RANK, Polyclonal Antibody
Full Product Name
Anti-RANK Antibody
Product Gene Name
anti-RANK antibody
Product Synonym Names
Tumor necrosis factor receptor superfamily member 11A; Activator of NFKB; CD 265; CD265; CD265 antigen; EOF; FEO; LOH18CR1; Loss of heterozygosity 18 chromosomal region 1; mRANK; NFKB activator; ODFR; OFE; OPTB7; Osteoclast differentiation factor receptor; OSTS; PDB 2; PDB2; RANK; Receptor activator of NF KB; Receptor activator of NF-KB; receptor activator of nuclear factor kappa B; TNFRSF 11A; TNFRSF11A; TNFSF11; TNR11_HUMAN; TRANCE R; TRANCER; Tumor necrosis factor receptor superfamily member 11a NFKB activator; Tumor necrosis factor receptor superfamily member 11a activator of NFKB; Tumor Necrosis Factor Receptor Superfamily Member 11a; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Clonality
Polyclonal
Species Reactivity
Mouse
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
66,621 Da
3D Structure
ModBase 3D Structure for O35305
Immunogen
E Coli-derived mouse RANK recombinant protein (Position: C35-S214). Mouse RANK shares 95.6% amino acid (aa) sequence identity with rat RANK.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-RANK antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RANK antibody
ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-RANK antibody

Anti- RANK Picoband antibody, MBS178245, Western blotting
All lanes: Anti RANK (MBS178245) at 0.5ug/ml
WB: HEPA Whole Cell Lysate at 40ug
Predicted bind size: 66KD
Observed bind size: 100KD
Anti-RANK Polyclonal Antibody – Cat# MBS178245

Product References and Citations for anti-RANK antibody

1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999). "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families". Endocr. Rev. 20 (3): 345-57. 2. Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795-823. 3. Wong BR, Josien R, Choi Y (1999). "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function". J. Leukoc. Biol. 65 (6): 715-24.

Other Notes

Small volumes of anti-RANK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RANK purchase

MBS178245 is an antibody targeting RANK. Reactive in Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for RANK. It may not necessarily be applicable to this product.

NCBI GI #
110350009
NCBI GeneID
21934
NCBI Accession #
NP_033425.3
UniProt Primary Accession #
O35305
UniProt Secondary Accession #
Q8VCT7
UniProt Related Accession #
O35305
GenBank Nucleotide #
NM_009399.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 11A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
NCBI Official Symbol
Tnfrsf11a
NCBI Official Synonym Symbols
OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11A
UniProt Synonym Protein Names
Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD_antigen: CD265
Protein Family
Rabankyrin
UniProt Gene Name
Tnfrsf11a
UniProt Synonym Gene Names
Rank; ODFR
UniProt Entry Name
TNR11_MOUSE
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11A

UniProt Comments for RANK

TNFRSF11A: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Protein type: Membrane protein, integral

Cellular Component: cell surface; external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: cytokine binding; metal ion binding; protein binding; transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; circadian thermoregulation; immune response; lymph node development; multicellular organismal development; ossification; osteoclast differentiation; positive regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of transcription factor activity; regulation of apoptosis; regulation of cell proliferation; response to cytokine stimulus; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway
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Research Articles on RANK

1. findings have uncovered a tumorigenic role for RANKL/RANK in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment of this understudied head and neck cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RANK antibody

 Reference Product  PubMed Publications
 Tnfsf11 antibody  >1513 publications with RANK and Tnfsf11
 Traf6 antibody  >65 publications with RANK and Traf6
 Fos antibody  >49 publications with RANK and Fos
 Src antibody  >38 publications with RANK and Src
 Traf2 antibody  >15 publications with RANK and Traf2
 Traf1 antibody  >8 publications with RANK and Traf1
 Traf5 antibody  >8 publications with RANK and Traf5
 Traf3 antibody  >6 publications with RANK and Traf3

Pathways associated with anti-RANK antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoclast Pathway antibodies  Osteoclast Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram

Diseases associated with anti-RANK antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >893 publications with RANK and Necrosis
 Inflammation Antibodies  >155 publications with RANK and Inflammation
 Cardiovascular Diseases Antibodies  >112 publications with RANK and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >66 publications with RANK and Breast Neoplasms
 Osteitis Deformans Antibodies  >53 publications with RANK and Osteitis Deformans
 Neoplasm Metastasis Antibodies  >44 publications with RANK and Neoplasm Metastasis
 Osteosarcoma Antibodies  >33 publications with RANK and Osteosarcoma
 Kidney Diseases Antibodies  >24 publications with RANK and Kidney Diseases
 Neoplasms, Experimental Antibodies  >23 publications with RANK and Neoplasms, Experimental
 Atherosclerosis Antibodies  >19 publications with RANK and Atherosclerosis

Organs/Tissues associated with anti-RANK antibody

 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >78 publications with RANK and Spleen
 Prostate Antibodies  >37 publications with RANK and Prostate
 Mammary Gland Antibodies  >29 publications with RANK and Mammary Gland
 Liver Antibodies  >22 publications with RANK and Liver
 Brain Antibodies  >21 publications with RANK and Brain
 Kidney Antibodies  >20 publications with RANK and Kidney
 Thymus Antibodies  >17 publications with RANK and Thymus
 Intestine Antibodies  >9 publications with RANK and Intestine
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