Rabbit Anti-RPS6KA1 Polyclonal Antibody – Cat# MBS6343918

Mouse Rps6ka1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Rps6ka1 antibody detected the Rps6ka1 protein (arrow).

RPS6KA1 Antibody – Rabbit Polyclonal

Name: RPS6KA1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6343918
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6343918

Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB (By similarity). More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Rps6ka1, Polyclonal Antibody

Full Product Name

Rps6ka1, CT (Rps6ka1, Mapkapk1a, Rsk1, Ribosomal protein S6 kinase alpha-1, 90kD ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, Ribosomal S6 kinase 1) (PE)

Product Gene Name

anti-Rps6ka1 antibody

Product Synonym Names

Rps6ka1; Mapkapk1a; Rsk1; Ribosomal protein S6 kinase alpha-1; 90kD ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; Ribosomal S6 kinase 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

81,595 Da

3D Structure

ModBase 3D Structure for P18653

Immunogen

Mouse Rps6ka1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 555-584 amino acids from the C-terminal region of Mouse Rps6ka1.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-Rps6ka1 antibody

Antibodies; Protein Kinases

Applications Tested/Suitable for anti-Rps6ka1 antibody

Western Blot (WB), FLISA

Application Notes for anti-Rps6ka1 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-Rps6ka1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rps6ka1 purchase

MBS6343918 is an antibody targeting Rps6ka1. Also known as Rps6ka1, CT (Rps6ka1, Mapkapk1a, Rsk1, Ribosomal protein S6 kinase alpha-1, 90kD ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, Ribosomal S6 kinase 1) (PE). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Rps6ka1. It may not necessarily be applicable to this product.

NCBI GI #

125690

NCBI GeneID

20111

NCBI Accession #

P18653.1

UniProt Primary Accession #

P18653

UniProt Related Accession #

P18653

NCBI Official Full Name

Ribosomal protein S6 kinase alpha-1

NCBI Official Synonym Full Names

ribosomal protein S6 kinase polypeptide 1

NCBI Official Symbol

Rps6ka1

NCBI Official Synonym Symbols

Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1

UniProt Protein Name

Ribosomal protein S6 kinase alpha-1

UniProt Synonym Protein Names

90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1

Protein Family

Ribosomal protein S6 kinase

UniProt Gene Name

Rps6ka1

UniProt Synonym Gene Names

Mapkapk1a; Rsk1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1

UniProt Entry Name

KS6A1_MOUSE

NCBI Protein Information

ribosomal protein S6 kinase alpha-1

UniProt Comments for Rps6ka1

p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Translation; AGC group; RSK family; RSK subfamily

Cellular Component: cytoplasm; nucleus; spindle

Molecular Function: ATP binding; caspase inhibitor activity; kinase activity; magnesium ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transcription factor binding; transferase activity

Biological Process: negative regulation of apoptosis; negative regulation of caspase activity; phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation

Research Articles on Rps6ka1

1. IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes, while it does not affect the activation of AKT.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Rps6ka1 antibody

Reference Product	PubMed Publications
Mapk1 antibody	>32 publications with Rps6ka1 and Mapk1
Eif4ebp1 antibody	>28 publications with Rps6ka1 and Eif4ebp1
Mapk3 antibody	>28 publications with Rps6ka1 and Mapk3
Rptor antibody	>10 publications with Rps6ka1 and Rptor
Tsc2 antibody	>10 publications with Rps6ka1 and Tsc2
Creb1 antibody	>4 publications with Rps6ka1 and Creb1
Pdpk1 antibody	>3 publications with Rps6ka1 and Pdpk1
Cebpb antibody	>1 publications with Rps6ka1 and Cebpb

Pathways associated with anti-Rps6ka1 antibody

Products by Pathway	Pathway Diagram
Activated TLR4 Signalling Pathway antibodies	Activated TLR4 Signalling Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
CREB Phosphorylation Pathway antibodies	CREB Phosphorylation Pathway Diagram
CREB Phosphorylation Through The Activation Of Ras Pathway antibodies	CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Cytoplasmic Ribosomal Proteins Pathway antibodies	Cytoplasmic Ribosomal Proteins Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram
ERK/MAPK Targets Pathway antibodies	ERK/MAPK Targets Pathway Diagram

Diseases associated with anti-Rps6ka1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>22 publications with Rps6ka1 and Inflammation
Nervous System Diseases Antibodies	>17 publications with Rps6ka1 and Nervous System Diseases
Disease Models, Animal Antibodies	>14 publications with Rps6ka1 and Disease Models, Animal
Hypertrophy Antibodies	>14 publications with Rps6ka1 and Hypertrophy
Liver Diseases Antibodies	>11 publications with Rps6ka1 and Liver Diseases
Necrosis Antibodies	>10 publications with Rps6ka1 and Necrosis
Cardiovascular Diseases Antibodies	>9 publications with Rps6ka1 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>9 publications with Rps6ka1 and Breast Neoplasms
Fatty Liver Antibodies	>8 publications with Rps6ka1 and Fatty Liver
Hyperplasia Antibodies	>6 publications with Rps6ka1 and Hyperplasia

Organs/Tissues associated with anti-Rps6ka1 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>56 publications with Rps6ka1 and Muscle
Blood Antibodies	>36 publications with Rps6ka1 and Blood
Liver Antibodies	>31 publications with Rps6ka1 and Liver
Brain Antibodies	>30 publications with Rps6ka1 and Brain
Heart Antibodies	>27 publications with Rps6ka1 and Heart
Lung Antibodies	>13 publications with Rps6ka1 and Lung
Kidney Antibodies	>7 publications with Rps6ka1 and Kidney
Bone Antibodies	>6 publications with Rps6ka1 and Bone
Intestine Antibodies	>5 publications with Rps6ka1 and Intestine
Skin Antibodies	>5 publications with Rps6ka1 and Skin