S100A6 Antibody – Rabbit Polyclonal

S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. S100A6 (S100 calcium-binding protein A6) is a member of the S100 family of proteins, and functions in prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of S100A6 have been implicated in melanoma.

Schafer, B.W. et al., 1996, Trends Biochem. Sci. 21 (4): 134-140. Donato, R. et al., 2003, Microsc. Res. Tech. 60 (6): 540-551. Nowotny, M. et al., 2003, J. Biol. Chem. 278 (29): 26923-26928. Nonaka D, et al., 2008, J. Cutan. Pathol. 35 (11): 1014-1019. Marenholz, I. et al., 2004, Biochem. Biophys. Res. Commun. 322 (4): 1111-22.

Small volumes of anti-S100A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8111232 is an antibody targeting S100A6. Also known as Anti-S100A6 Antibody, Rabbit Polyclonal. Reactive in Mouse. Host: Rabbit.