Rabbit Anti-SAMD8 Polyclonal Antibody – Cat# MBS6344920

Western blot analysis of SAMD8 Antibody (N-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in mouse liver tissue lysate. SAMD8 Antibody (N-term) (arrow) was detected using the purified Pab.

SAMD8 Antibody – Rabbit Polyclonal

Name: SAMD8 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6344920
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6344920

MBS6344920 is an antibody targeting SAMD8. Also known as SAMD8, NT (SAMD8, Sphingomyelin synthase-related protein 1, Sterile alpha motif domain-containing protein 8) (AP). Reactive in Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SAMD8, Polyclonal Antibody

Full Product Name

SAMD8, NT (SAMD8, Sphingomyelin synthase-related protein 1, Sterile alpha motif domain-containing protein 8) (AP)

Product Gene Name

anti-SAMD8 antibody

Product Synonym Names

SAMD8; Sphingomyelin synthase-related protein 1; Sterile alpha motif domain-containing protein 8

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

37,609 Da

OMIM

611575

3D Structure

ModBase 3D Structure for Q96LT4

Immunogen

SAMD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the N-terminal region of human SAMD8.

Conjugate

Note

Preservative Free

Product Categories/Family for anti-SAMD8 antibody

Antibodies; Enzymes; Synthase

Applications Tested/Suitable for anti-SAMD8 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-SAMD8 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-SAMD8 antibody

Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006). Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005). Huitema, K., et al. EMBO J. 23(1):33-44(2004).

Other Notes

Small volumes of anti-SAMD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SAMD8. It may not necessarily be applicable to this product.

NCBI GI #

21389545

NCBI GeneID

142891

NCBI Accession #

NP_653261.1

UniProt Primary Accession #

Q96LT4

UniProt Secondary Accession #

Q5JSC5; Q5JSC8; Q66K52

UniProt Related Accession #

Q96LT4

GenBank Nucleotide #

NM_144660.2

NCBI Official Full Name

sphingomyelin synthase-related protein 1 isoform 2

NCBI Official Synonym Full Names

sterile alpha motif domain containing 8

NCBI Official Symbol

SAMD8

NCBI Official Synonym Symbols

SMSr; HEL-177

UniProt Protein Name

Sphingomyelin synthase-related protein 1

UniProt Synonym Protein Names

Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8

Protein Family

Sphingomyelin synthase-related protein

UniProt Gene Name

SAMD8

UniProt Synonym Gene Names

SMSr; CPE synthase

UniProt Entry Name

SAMD8_HUMAN

NCBI Protein Information

sphingomyelin synthase-related protein 1

UniProt Comments for SAMD8

SAMD8: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Belongs to the sphingomyelin synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: integral to membrane; integral to endoplasmic reticulum membrane

Molecular Function: transferase activity

Biological Process: ceramide biosynthetic process; sphingomyelin biosynthetic process

Research Articles on SAMD8

1. These results indicate a primary role of SMSr in monitoring endoplasmic reticulum ceramide levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SAMD8 antibody

Products by Pathway	Pathway Diagram
Sphingomyelin Metabolism/ceramide Salvage Pathway antibodies	Sphingomyelin Metabolism/ceramide Salvage Pathway Diagram