Rabbit Anti-TBK1 Polyclonal Antibody – Cat# MBS9203960

Mouse Tbk1 Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the Tbk1 antibody detected the Tbk1 protein (arrow).

TBK1 Antibody – Rabbit Polyclonal

Name: TBK1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9203960
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9203960

Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also… More details

$240 / 0.08 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tbk1, Polyclonal Antibody

Full Product Name

Mouse Tbk1 Antibody (N-term)

Product Gene Name

anti-Tbk1 antibody

Product Synonym Names

Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; Tbk1

Clonality

Polyclonal

Isotype

Rabbit Ig

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Purity/Purification

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Concentration

Vial Concentration: 0.5 (lot specific)

Specificity

This Mouse Tbk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of mouse Tbk1.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

Tbk1 peptide (MBS9222474) is used for blocking the activity of Tbk1 antibody (MBS9203960)

Molecular Weight

83425

Immunogen Sequence Positions

8-35

3D Structure

ModBase 3D Structure for Q9WUN2

Antigen Type

Synthetic Peptide

Antigen Source

MOUSE

Product Categories/Family for anti-Tbk1 antibody

Signal Transduction

Applications Tested/Suitable for anti-Tbk1 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-Tbk1 antibody

WB~~1:1000

Product References and Citations for anti-Tbk1 antibody

Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010)
Watanabe, T., et al. J. Clin. Invest. 120(5):1645-1662(2010)
Gabhann, J.N., et al. J. Immunol. 184(5):2314-2320(2010)
Munoz, M.C., et al. J. Endocrinol. 201(2):185-197(2009)
Miyahira, A.K., et al. J. Immunol. 182(4):2248-2257(2009)

Other Notes

Small volumes of anti-Tbk1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tbk1 purchase

MBS9203960 is an antibody targeting Tbk1. Also known as Mouse Tbk1 Antibody (N-term). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tbk1. It may not necessarily be applicable to this product.

NCBI GI #

251823839

NCBI GeneID

56480

NCBI Accession #

NP_062760.3

UniProt Primary Accession #

Q9WUN2

UniProt Secondary Accession #

Q9CT90; Q9DC03

UniProt Related Accession #

Q9WUN2

GenBank Nucleotide #

NM_019786.4

NCBI Official Full Name

serine/threonine-protein kinase TBK1

NCBI Official Synonym Full Names

TANK-binding kinase 1

NCBI Official Symbol

Tbk1

NCBI Official Synonym Symbols

AI462036; AW048562; 1200008B05Rik

UniProt Protein Name

Serine/threonine-protein kinase TBK1

UniProt Synonym Protein Names

T2K; TANK-binding kinase 1

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

Tbk1

UniProt Entry Name

TBK1_MOUSE

NCBI Protein Information

serine/threonine-protein kinase TBK1

UniProt Comments for Tbk1

TBK1: a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; IKK family

Cellular Component: cytoplasm

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; nucleic acid binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phosphoprotein binding; kinase activity; ATP binding; protein kinase activity

Biological Process: defense response to Gram-positive bacterium; immune system process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; defense response to virus; phosphorylation; activation of innate immune response; positive regulation of interferon-alpha production

Research Articles on Tbk1

1. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Tbk1 antibody

Reference Product	PubMed Publications
Irf3 antibody	>261 publications with Tbk1 and Irf3
Tank antibody	>242 publications with Tbk1 and Tank
Mavs antibody	>51 publications with Tbk1 and Mavs
Traf3 antibody	>38 publications with Tbk1 and Traf3
Ddx3x antibody	>9 publications with Tbk1 and Ddx3x
Traf2 antibody	>9 publications with Tbk1 and Traf2
Ikbkg antibody	>7 publications with Tbk1 and Ikbkg
Tnfaip3 antibody	>6 publications with Tbk1 and Tnfaip3
Tmem173 antibody	>5 publications with Tbk1 and Tmem173

Pathways associated with anti-Tbk1 antibody

Products by Pathway	Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
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Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram
Beta-Alanine Metabolism Pathway antibodies	Beta-Alanine Metabolism Pathway Diagram

Diseases associated with anti-Tbk1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>71 publications with Tbk1 and Inflammation
Necrosis Antibodies	>59 publications with Tbk1 and Necrosis
Liver Diseases Antibodies	>20 publications with Tbk1 and Liver Diseases
Lung Neoplasms Antibodies	>14 publications with Tbk1 and Lung Neoplasms
Cell Transformation, Neoplastic Antibodies	>9 publications with Tbk1 and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>8 publications with Tbk1 and Breast Neoplasms
Atherosclerosis Antibodies	>8 publications with Tbk1 and Atherosclerosis
Kidney Diseases Antibodies	>7 publications with Tbk1 and Kidney Diseases
Insulin Resistance Antibodies	>7 publications with Tbk1 and Insulin Resistance
Carcinoma, Hepatocellular Antibodies	>5 publications with Tbk1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-Tbk1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>54 publications with Tbk1 and Blood
Bone Antibodies	>25 publications with Tbk1 and Bone
Lung Antibodies	>24 publications with Tbk1 and Lung
Bone Marrow Antibodies	>23 publications with Tbk1 and Bone Marrow
Liver Antibodies	>20 publications with Tbk1 and Liver
Brain Antibodies	>16 publications with Tbk1 and Brain
Kidney Antibodies	>14 publications with Tbk1 and Kidney
Eye Antibodies	>12 publications with Tbk1 and Eye
Skin Antibodies	>8 publications with Tbk1 and Skin
Spleen Antibodies	>6 publications with Tbk1 and Spleen