TSC1 Antibody – Rabbit Polyclonal

TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Cellular Component: TSC1-TSC2 complex; growth cone; protein complex; cytoskeleton; membrane; intracellular membrane-bound organelle; lamellipodium; cytoplasm; plasma membrane; actin filament; cell cortex; cytosol

Molecular Function: protein binding; chaperone binding; GTPase activating protein binding; protein N-terminus binding; GTPase regulator activity

Biological Process: myelination; protein heterooligomerization; regulation of cell cycle; regulation of cell-matrix adhesion; cell-matrix adhesion; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; regulation of phosphoprotein phosphatase activity; cardiac muscle cell differentiation; response to insulin stimulus; regulation of translation; negative regulation of cell proliferation; cell projection organization and biogenesis; positive regulation of focal adhesion formation; synapse organization and biogenesis; kidney development; potassium ion transport; nervous system development; regulation of GTPase activity; negative regulation of TOR signaling pathway; protein stabilization; hippocampus development; rRNA export from nucleus; embryonic development; regulation of actin cytoskeleton organization and biogenesis; glucose import; regulation of stress fiber formation; negative regulation of translation; neural tube closure; regulation of focal adhesion formation; cerebral cortex development; regulation of protein kinase activity