Rabbit Anti-ULK3 Polyclonal Antibody – Cat# MBS6361397

ULK3 Antibody – Rabbit Polyclonal

Name: ULK3 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6361397
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6361397

Serine/threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI-dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ULK3, Polyclonal Antibody

Full Product Name

ULK3, CT (ULK3, Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3) (MaxLight 750)

Product Gene Name

anti-ULK3 antibody

Product Synonym Names

ULK3; Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

53,444 Da

Chromosome Location

Chromosome: 15; NC_000015.9 (75128459..75135552, complement). Location: 15q24.1

OMIM

613472

3D Structure

ModBase 3D Structure for Q6PHR2

Immunogen

ULK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from the C-terminal region of human ULK3.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-ULK3 antibody

Antibodies; Protein Kinases

Applications Tested/Suitable for anti-ULK3 antibody

Western Blot (WB), FLISA

Application Notes for anti-ULK3 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ULK3 antibody

Maloverjan, A., et al. J. Biol. Chem. 285(39):30079-30090(2010). Takeuchi, F., et al. Circulation 121(21):2302-2309(2010). Maloverjan, A., et al. Exp. Cell Res. 316(4):627-637(2010). Levy, D., et al. Nat. Genet. 41(6):677-687(2009). Kim, D.H., et al. Blood 113(11):2517-2525(2009).

Other Notes

Small volumes of anti-ULK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ULK3 purchase

MBS6361397 is an antibody targeting ULK3. Also known as ULK3, CT (ULK3, Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3) (MaxLight 750). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ULK3. It may not necessarily be applicable to this product.

NCBI GI #

150456432

NCBI GeneID

25989

NCBI Accession #

NP_001092906.1

UniProt Primary Accession #

Q6PHR2

UniProt Secondary Accession #

Q9NPN5; Q9UFS4; B2RXK3; B4DRQ7; D3DW68

UniProt Related Accession #

Q6PHR2

GenBank Nucleotide #

NM_001099436.1

NCBI Official Full Name

serine/threonine-protein kinase ULK3

NCBI Official Synonym Full Names

unc-51-like kinase 3 (C. elegans)

NCBI Official Symbol

ULK3

UniProt Protein Name

Serine/threonine-protein kinase ULK3

UniProt Synonym Protein Names

Unc-51-like kinase 3

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

ULK3

UniProt Entry Name

ULK3_HUMAN

NCBI Protein Information

serine/threonine-protein kinase ULK3

UniProt Comments for ULK3

ULK3: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; ULK family

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: negative regulation of smoothened signaling pathway; protein amino acid autophosphorylation; positive regulation of smoothened signaling pathway; autophagy; regulation of autophagy; autophagic vacuole formation

Research Articles on ULK3

1. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ULK3 antibody

Disease Name	Pubmed Publications
Vascular Diseases Antibodies	>4 publications with ULK3 and Vascular Diseases
Mental Disorders Antibodies	>1 publications with ULK3 and Mental Disorders
Drug Toxicity Antibodies	>1 publications with ULK3 and Drug Toxicity
Brain Diseases Antibodies	>1 publications with ULK3 and Brain Diseases

Organs/Tissues associated with anti-ULK3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with ULK3 and Blood
Liver Antibodies	>2 publications with ULK3 and Liver
Embryonic Tissue Antibodies	>2 publications with ULK3 and Embryonic Tissue
Heart Antibodies	>1 publications with ULK3 and Heart
Muscle Antibodies	>1 publications with ULK3 and Muscle
Lung Antibodies	>1 publications with ULK3 and Lung