Complement Component 5a (C5A) Antibody – Rabbit Polyclonal

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: apical part of cell; basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: complement component C5a receptor activity; G-protein coupled receptor activity

Biological Process: activation of MAPK activity; cellular defense response; chemotaxis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; inflammatory response; leukocyte migration; mRNA transcription from RNA polymerase II promoter; phospholipase C activation; positive regulation of epithelial cell proliferation; regulation of complement activation; sensory perception of chemical stimulus; signal transduction