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IFIT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9434427

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IFIT1, Polyclonal Antibody
Full Product Name
IFIT1 Polyclonal Antibody
Product Gene Name
anti-IFIT1 antibody
Product Synonym Names
IFIT1; C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1; IFNAI1; ISG56; P56; RNM561; interferon-induced protein with tetratricopeptide repeats 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
PBS with 50% glycerol, pH7.4
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
55,360 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (91152303..91166244). Location: 10q23.31
OMIM
147690
3D Structure
ModBase 3D Structure for P09914
Immunogen
Recombinant fusion protein of human IFIT1 (NP_001539.3).
Conjugation
Unconjugated

Product Categories/Family for anti-IFIT1 antibody

Total protein Ab
Applications Tested/Suitable for anti-IFIT1 antibody
Western Blot (WB)
Application Notes for anti-IFIT1 antibody
WB: 1:200-1:2000

Western Blot (WB) of anti-IFIT1 antibody

Western blot analysis of extracts of various cell lines, using IFIT1 antibody.
Rabbit Anti-IFIT1 Polyclonal Antibody – Cat# MBS9434427

Other Notes

Small volumes of anti-IFIT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFIT1 purchase

MBS9434427 is an antibody targeting IFIT1. Also known as IFIT1 Polyclonal Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IFIT1. It may not necessarily be applicable to this product.

NCBI GI #
116534937
NCBI GeneID
3434
NCBI Accession #
NP_001539.3
UniProt Primary Accession #
P09914
UniProt Secondary Accession #
Q5T7J1; Q96QM5
UniProt Related Accession #
P09914
GenBank Nucleotide #
NM_001548.4
NCBI Official Full Name
interferon-induced protein with tetratricopeptide repeats 1 isoform 1
NCBI Official Synonym Full Names
interferon-induced protein with tetratricopeptide repeats 1
NCBI Official Symbol
IFIT1
NCBI Official Synonym Symbols
C56; P56; G10P1; IFI56; ISG56; IFI-56; IFIT-1; IFNAI1; RNM561; IFI-56K
UniProt Protein Name
Interferon-induced protein with tetratricopeptide repeats 1
UniProt Synonym Protein Names
Interferon-induced 56 kDa protein
Protein Family
Interferon-induced protein with tetratricopeptide repeats
UniProt Gene Name
IFIT1
UniProt Synonym Gene Names
G10P1; IFI56; IFNAI1; ISG56; IFIT-1; IFI-56K; P56
UniProt Entry Name
IFIT1_HUMAN
NCBI Protein Information
interferon-induced protein with tetratricopeptide repeats 1; interferon-inducible mRNA 561; interferon-induced 56 kDa protein; interferon, alpha-inducible protein (MW 56kD)

UniProt Comments for IFIT1

IFIT1: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. Belongs to the IFIT family.

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; RNA binding

Biological Process: intracellular transport of viral proteins in host cell; negative regulation of helicase activity; positive regulation of viral genome replication; negative regulation of viral genome replication; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of defense response to virus by host; negative regulation of protein binding; defense response to virus
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Research Articles on IFIT1

1. Data suggested that PIV5 mRNAs are methylated at the 2'-hydroxyl group and that ISG56/IFIT1 inhibits the translation of PIV5 mRNA by some unrecognized mechanism. Also ISG56/IFIT1 is primarily responsible for the IFN-induced inhibition of PIV5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFIT1 antibody

 Reference Product  PubMed Publications
 IFIT3 antibody  >18 publications with IFIT1 and IFIT3
 EIF3E antibody  >4 publications with IFIT1 and EIF3E

Pathways associated with anti-IFIT1 antibody

 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram

Diseases associated with anti-IFIT1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with IFIT1 and Neoplasms
 Inflammation Antibodies  >10 publications with IFIT1 and Inflammation
 Liver Diseases Antibodies  >7 publications with IFIT1 and Liver Diseases
 Necrosis Antibodies  >4 publications with IFIT1 and Necrosis
 Carcinoma Antibodies  >3 publications with IFIT1 and Carcinoma
 Breast Neoplasms Antibodies  >2 publications with IFIT1 and Breast Neoplasms
 Lung Diseases Antibodies  >2 publications with IFIT1 and Lung Diseases
 Drug Toxicity Antibodies  >2 publications with IFIT1 and Drug Toxicity
 Cognition Disorders Antibodies  >1 publications with IFIT1 and Cognition Disorders
 Neoplasms, Experimental Antibodies  >1 publications with IFIT1 and Neoplasms, Experimental

Organs/Tissues associated with anti-IFIT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with IFIT1 and Blood
 Liver Antibodies  >7 publications with IFIT1 and Liver
 Brain Antibodies  >7 publications with IFIT1 and Brain
 Kidney Antibodies  >6 publications with IFIT1 and Kidney
 Lung Antibodies  >6 publications with IFIT1 and Lung
 Bone Antibodies  >4 publications with IFIT1 and Bone
 Intestine Antibodies  >2 publications with IFIT1 and Intestine
 Muscle Antibodies  >2 publications with IFIT1 and Muscle
 Uterus Antibodies  >2 publications with IFIT1 and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with IFIT1 and Uncharacterized Tissue
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