NR4A2 Antibody – Rabbit Polyclonal

NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; steroid hormone receptor activity; transcription factor activity

Biological Process: positive regulation of catalytic activity; transcription from RNA polymerase II promoter; central nervous system neuron differentiation; adult locomotory behavior; positive regulation of transcription, DNA-dependent; neuron migration; dopamine biosynthetic process; response to insecticide; neuron maturation; dopamine metabolic process; post-embryonic development; neuron differentiation; regulation of respiratory gaseous exchange; general adaptation syndrome; regulation of transcription, DNA-dependent; negative regulation of neuron apoptosis; nervous system development; intracellular receptor-mediated signaling pathway; response to inorganic substance; transcription, DNA-dependent; death; response to amphetamine; regulation of dopamine metabolic process; central nervous system projection neuron axonogenesis; habenula development; regulation of transcription from RNA polymerase II promoter; regulation of gene expression; cellular response to extracellular stimulus; response to hypoxia; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling