TFB2M Antibody – Goat Polyclonal

TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

Protein type: Methyltransferase; Transcription, coactivator/corepressor; EC 2.1.1.-

Cellular Component: cell junction; mitochondrial matrix; mitochondrion

Molecular Function: 1-phenanthrol methyltransferase activity; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; arginine N-methyltransferase activity; C-methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; cobalt-precorrin-3 C17-methyltransferase activity; cobalt-precorrin-5B C1-methyltransferase activity; cobalt-precorrin-6B C5-methyltransferase activity; cobalt-precorrin-7 C15-methyltransferase activity; demethylmenaquinone methyltransferase activity; dimethylamine methyltransferase activity; DNA-methyltransferase activity; hydroxyneurosporene-O-methyltransferase activity; lysine N-methyltransferase activity; methanol-specific methylcobalamin:coenzyme M methyltransferase activity; methylamine-specific methylcobalamin:coenzyme M methyltransferase activity; methylarsonite methyltransferase activity; methyltransferase activity; monomethylamine methyltransferase activity; mRNA methyltransferase activity; N-methyltransferase activity; O-methyltransferase activity; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine N5-methyltransferase activity; protein-leucine O-methyltransferase activity; protein-lysine N-methyltransferase activity; RNA binding; RNA methyltransferase activity; rRNA (adenine) methyltransferase activity; rRNA (adenine-N6,N6-)-dimethyltransferase activity; rRNA (adenine-N6-)-methyltransferase activity; rRNA (cytosine) methyltransferase activity; rRNA (cytosine-C5-967)-methyltransferase activity; rRNA (guanine) methyltransferase activity; rRNA (uridine) methyltransferase activity; rRNA (uridine-2'-O-)-methyltransferase activity; rRNA methyltransferase activity; S-methyltransferase activity; selenocysteine methyltransferase activity; transcription cofactor activity; transferase activity; trimethylamine methyltransferase activity; tRNA (adenine)-methyltransferase activity; tRNA (adenine-57, 58-N(1)-) methyltransferase activity; tRNA (adenine-N1-)-methyltransferase activity; tRNA (cytosine)-methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; tRNA (guanine) methyltransferase activity; tRNA (guanine-N1-)-methyltransferase activity; tRNA (guanine-N2-)-methyltransferase activity; tRNA (uracil) methyltransferase activity; tRNA methyltransferase activity

Biological Process: methylation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; rRNA methylation; rRNA processing; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter; transcription, DNA-dependent