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TLR13 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641406

TLR13, also known as Toll like receptor 13, is a member of the Toll-like receptor (TLR) family of transmembrane proteins comprised of multiple copies of leucine rich repeats in the extracellular domain and a TIR domain. The exact function of this 991aa… More details

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Product Overview

Online Datasheet in PDF
Product Name
TLR13, Polyclonal Antibody
Full Product Name
TLR13 (Toll Like Receptor 13, Toll-like Receptor 13)
Product Gene Name
anti-Tlr13 antibody
Product Synonym Names
Anti -TLR13 (Toll Like Receptor 13, Toll-like Receptor 13)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse TLR13. Species Crossreactivity: rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
114,443 Da
Chromosome Location
Chromosome: X; NC_000086.7 (106143275..106160493). Location: X D; X
3D Structure
ModBase 3D Structure for Q6R5N8
Immunogen
Synthetic peptide corresponding to aa800 to 850 of mouse TLR13.

Product Categories/Family for anti-Tlr13 antibody

Antibodies; Abs to Toll Like Receptors (TLR)
Applications Tested/Suitable for anti-Tlr13 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Tlr13 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-3ug/ml

Western Blot (WB) of anti-Tlr13 antibody

Western blot analysis of TLR13 in rat corpus (tissue is from male rat reproductive tract) lysate in the 1) absence and 2) presence of immunizing peptide using MBS641406 at 1ug/ml. goat anti-rabbit Ig HRP secondary antibody and ECL substrate solution were used for this test.
Rabbit Anti-TLR13 Polyclonal Antibody – Cat# MBS641406

Other Notes

Small volumes of anti-Tlr13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tlr13 purchase

MBS641406 is an antibody targeting Tlr13. Also known as TLR13 (Toll Like Receptor 13, Toll-like Receptor 13). Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tlr13. It may not necessarily be applicable to this product.

NCBI GI #
45429999
NCBI GeneID
279572
NCBI Accession #
NP_991389.1
UniProt Primary Accession #
Q6R5N8
UniProt Secondary Accession #
Q148Y7; Q3TDS2
UniProt Related Accession #
Q6R5N8
GenBank Nucleotide #
NM_205820.1
NCBI Official Full Name
toll-like receptor 13
NCBI Official Synonym Full Names
toll-like receptor 13
NCBI Official Symbol
Tlr13
NCBI Official Synonym Symbols
Gm713; AI666735
UniProt Protein Name
Toll-like receptor 13
Protein Family
Toll-like receptor
UniProt Gene Name
Tlr13
UniProt Entry Name
TLR13_MOUSE
NCBI Protein Information
toll-like receptor 13

UniProt Comments for Tlr13

TLR13: Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane; cytoplasm; integral to membrane; endosome

Molecular Function: rRNA binding; protein binding; protein homodimerization activity; RNA binding

Biological Process: toll-like receptor 13 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; immune system process; response to virus; regulation of MAPKKK cascade; innate immune response; inflammatory response; signal transduction
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Research Articles on Tlr13

1. TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Tlr13 antibody

 Reference Product  PubMed Publications
 Unc93b1 antibody  >2 publications with Tlr13 and Unc93b1
 Myd88 antibody  >2 publications with Tlr13 and Myd88

Diseases associated with anti-Tlr13 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with Tlr13 and Inflammation
 Necrosis Antibodies  >1 publications with Tlr13 and Necrosis
 Pneumonia Antibodies  >1 publications with Tlr13 and Pneumonia

Organs/Tissues associated with anti-Tlr13 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with Tlr13 and Kidney
 Bone Antibodies  >1 publications with Tlr13 and Bone
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