Plasminogen, Affinity Purified (PLG) Antibody – Rabbit Polyclonal

Plasminogen: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Defects in PLG are the cause of plasminogen deficiency (PLGD). PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Belongs to the peptidase S1 family. Plasminogen subfamily.

Protein type: Motility/polarity/chemotaxis; EC 3.4.21.7; Protease; Secreted, signal peptide; Secreted

Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; extrinsic to external side of plasma membrane; intracellular membrane-bound organelle; cell; plasma membrane; extracellular region

Molecular Function: peptidase activity; protein domain specific binding; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity; apolipoprotein binding; catalytic activity; receptor binding

Biological Process: tissue remodeling; proteolysis; muscle maintenance; myoblast differentiation; extracellular matrix disassembly; fibrinolysis; negative regulation of angiogenesis; negative regulation of fibrinolysis; proteolysis involved in cellular protein catabolic process; hemostasis; tissue regeneration; positive regulation of fibrinolysis; blood coagulation