PPP2R3B Antibody – Rabbit Polyclonal

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

PPP2R3B: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp22.33; Yp11.3

Cellular Component: nucleoplasm; protein phosphatase type 2A complex; nucleus

Molecular Function: protein binding; protein phosphatase type 2A regulator activity; calcium ion binding; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: regulation of catalytic activity; mitotic cell cycle; protein amino acid dephosphorylation; cell cycle arrest; G1/S transition of mitotic cell cycle