Rabbit Anti-PSA Polyclonal Antibody – Cat# MBS6494819

Western blot analysis of anti-KLK3 Pab in mouse brain tissue lysate.KLK3(arrow) was detected using the purified Pab.

Prostate Specific Antigen (PSA) Antibody – Rabbit Polyclonal

Name: PSA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6494819
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6494819

MBS6494819 is an antibody targeting PSA. Also known as Prostate Specific Antigen, CT (PSA, APS, Kallikrein-3, KLK3, hK3, Kallikrein III, Kallikrein-related Peptidase 3, KLK2A1, P-30 Antigen, Seminin, Semenogelase, gamma-Seminoprotein) (MaxLight 750). Reactive… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Prostate Specific Antigen (PSA), Polyclonal Antibody

Full Product Name

Prostate Specific Antigen, CT (PSA, APS, Kallikrein-3, KLK3, hK3, Kallikrein III, Kallikrein-related Peptidase 3, KLK2A1, P-30 Antigen, Seminin, Semenogelase, gamma-Seminoprotein) (MaxLight 750)

Product Gene Name

anti-PSA antibody

Product Synonym Names

EC=3.4.21.77; Gamma-Seminoprotein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Ammonium Sulfate Precipitation.

Specificity

Recognizes human KLK3.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

28.8 kDa (262aa)

OMIM

176820

3D Structure

ModBase 3D Structure for P07288

Immunogen

Synthetic peptide selected from the C-terminal region of human KLK3 (KLH).

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-PSA antibody

Antibodies; Cancer Markers

Applications Tested/Suitable for anti-PSA antibody

Western Blot (WB), FLISA

Application Notes for anti-PSA antibody

WB: 1:100-1:500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PSA antibody

1. Binnie, M.C., et al., Prostate 63(4):309-315 (2005). 2. Habib, F.K., et al., Int. J. Cancer 114(2):190-194 (2005). 3. Laidler, P., et al., Arch. Biochem. Biophys. 435(1):1-14 (2005). 4. Dallas, S.L., et al., J. Cell. Physiol. 202(2):361-370 (2005). 5. Olsson, A.Y., et al., Genomics 84(1):147-156 (2004).

Other Notes

Small volumes of anti-PSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PSA. It may not necessarily be applicable to this product.

NCBI GI #

4502173

NCBI GeneID

354

NCBI Accession #

NP_001639

UniProt Primary Accession #

P07288

UniProt Secondary Accession #

Q15096; Q16272; Q86TG8; Q8IXI4; C9JXH3; G3V0H4; G3XAE3

UniProt Related Accession #

P07288

GenBank Nucleotide #

NM_001648.2

NCBI Official Full Name

prostate-specific antigen isoform 1 preproprotein

NCBI Official Synonym Full Names

kallikrein related peptidase 3

NCBI Official Symbol

KLK3

NCBI Official Synonym Symbols

APS; PSA; hK3; KLK2A1

UniProt Protein Name

Prostate-specific antigen

UniProt Synonym Protein Names

Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

Protein Family

Prostate-specific antigen

UniProt Gene Name

KLK3

UniProt Synonym Gene Names

APS; PSA; Seminin

UniProt Entry Name

KLK3_HUMAN

NCBI Protein Information

prostate-specific antigen

NCBI Summary for PSA

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for PSA

PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: Secreted; Protease; EC 3.4.21.77; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region; nucleus

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis

Research Articles on PSA

1. the concentrations of insulin, IGF-1, IGFBP-3 and their association with prostate size in patients with BPH

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSA antibody

Reference Product	PubMed Publications
TP53 antibody	>2 publications with PSA and TP53
ERBB2 antibody	>2 publications with PSA and ERBB2
IL6 antibody	>1 publications with PSA and IL6

Pathways associated with anti-PSA antibody

Products by Pathway	Pathway Diagram
Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway antibodies	Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram
FOXA1 Transcription Factor Network Pathway antibodies	FOXA1 Transcription Factor Network Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Prostate Cancer Pathway antibodies	Prostate Cancer Pathway Diagram
Prostate Cancer Pathway antibodies	Prostate Cancer Pathway Diagram

Diseases associated with anti-PSA antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>86 publications with PSA and Neoplasms
Prostatic Neoplasms Antibodies	>65 publications with PSA and Prostatic Neoplasms
Adenocarcinoma Antibodies	>13 publications with PSA and Adenocarcinoma
Breast Neoplasms Antibodies	>13 publications with PSA and Breast Neoplasms
Hyperplasia Antibodies	>7 publications with PSA and Hyperplasia
Disease Progression Antibodies	>7 publications with PSA and Disease Progression
Neoplasms, Experimental Antibodies	>6 publications with PSA and Neoplasms, Experimental
Ovarian Neoplasms Antibodies	>6 publications with PSA and Ovarian Neoplasms
Kidney Diseases Antibodies	>6 publications with PSA and Kidney Diseases
Neoplasm Metastasis Antibodies	>5 publications with PSA and Neoplasm Metastasis

Organs/Tissues associated with anti-PSA antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>112 publications with PSA and Prostate
Salivary Gland Antibodies	>4 publications with PSA and Salivary Gland
Brain Antibodies	>4 publications with PSA and Brain
Bone Antibodies	>3 publications with PSA and Bone
Muscle Antibodies	>2 publications with PSA and Muscle
Nerve Antibodies	>2 publications with PSA and Nerve
Adrenal Gland Antibodies	>1 publications with PSA and Adrenal Gland