Poly U Binding Splicing Factor 60kDa (PUF60) Antibody – Rabbit Polyclonal

This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

FIR: fuse-binding protein-interacting repressor. Interacts with (and may activate) Ro RNPs. Forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. Two alternatively spliced isoforms have been described.

Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cell junction; cyclin-dependent protein kinase activating kinase holoenzyme complex; intracellular ribonucleoprotein complex; nucleoplasm

Molecular Function: cadherin binding; DNA binding; identical protein binding; protein binding; RNA binding

Biological Process: apoptosis; mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; transcription, DNA-dependent

Disease: Verheij Syndrome