Mgcracgap (RACGAP1) Antibody – Rabbit Polyclonal

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: acrosome; cleavage furrow; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; microtubule; midbody; nucleoplasm; nucleus; spindle midzone

Molecular Function: alpha-tubulin binding; beta-tubulin binding; gamma-tubulin binding; GTPase activator activity; metal ion binding; microtubule binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein kinase binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; cytokinesis after mitosis; cytokinesis, contractile ring formation; embryonic development; microtubule-based movement; neuroblast proliferation; positive regulation of cytokinesis; positive regulation of GTPase activity; regulation of attachment of spindle microtubules to kinetochore; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; spermatogenesis; spindle midzone assembly involved in mitosis; sulfate transport