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CLC4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS615019

Chloride is a critical component of all living cells. Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential… More details

$905 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLC4, Polyclonal Antibody
Full Product Name
CLC4 (Clcn4, Chloride Channel)
Product Synonym Names
Anti -CLC4 (Clcn4, Chloride Channel)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide.
Purity/Purification
Serum
Serum
Specificity
Recognizes rat CLC4 (Clcn4, Chloride Channel). No significant sequence homology is detected with other CLCs or other proteins. Species sequence homology: mouse and human, 100%.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
A synthetic peptide corresponding to 13aa near the C-terminus of rat CLC-4 (KLH).

Product Categories/Family for anti-CLC4 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-CLC4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CLC4 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot (ECL): 1:1000-1:5000
ELISA: 1:10,000-50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.

Other Notes

Small volumes of anti-CLC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLC4 purchase

MBS615019 is an antibody targeting CLC4. Also known as CLC4 (Clcn4, Chloride Channel). Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLC4. It may not necessarily be applicable to this product.

NCBI GI #
5759112
NCBI Official Full Name
chloride channel CLC4

NCBI Summary for CLC4

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
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UniProt Comments for CLC4

CLCN4: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: late endosome membrane; early endosome membrane; integral to membrane; endosome membrane

Molecular Function: chloride channel activity; voltage-gated chloride channel activity; ATP binding; antiporter activity

Biological Process: transport; chloride transport; transmembrane transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLC4 antibody

 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with CLC4 and FLNA

Pathways associated with anti-CLC4 antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Organs/Tissues associated with anti-CLC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with CLC4 and Bone
 Connective Tissue Antibodies  >4 publications with CLC4 and Connective Tissue
 Heart Antibodies  >3 publications with CLC4 and Heart
 Muscle Antibodies  >3 publications with CLC4 and Muscle
 Brain Antibodies  >3 publications with CLC4 and Brain
 Vascular Antibodies  >2 publications with CLC4 and Vascular
 Embryonic Tissue Antibodies  >2 publications with CLC4 and Embryonic Tissue
 Ear Antibodies  >1 publications with CLC4 and Ear
 Kidney Antibodies  >1 publications with CLC4 and Kidney
 Umbilical Cord Antibodies  >1 publications with CLC4 and Umbilical Cord
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