FGR Antibody – Rabbit Polyclonal

FGR: a non-receptor tyrosine kinase of the Src family. Contains one SH2 and one SH3 domain. Beta 2 integrin signaling induces its c-Cbl-mediated ubiquitination in adherent neutrophils. An ortholog of v-fgr feline oncogene. Mildly amplified in hormone-resistant prostate cancer. Copy number either increased or decreased in other cancers.

Protein type: Oncoprotein; Mitochondrial; EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Src family

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cell projection; membrane; mitochondrion; cytoplasm; mitochondrial inner membrane; plasma membrane; cytosol; actin cytoskeleton

Molecular Function: transferase activity; protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; immune system process; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of mast cell degranulation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of innate immune response; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; defense response to Gram-positive bacterium; regulation of actin cytoskeleton organization and biogenesis; innate immune response; cell differentiation; regulation of protein kinase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cytokine secretion; positive regulation of cell migration