Fibronectin (FN1) Antibody – Rabbit Polyclonal

FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; fibrinogen complex; apical plasma membrane; extracellular region; ER-Golgi intermediate compartment; basement membrane; basal lamina

Molecular Function: heparin binding; integrin binding; protein binding; protease activator activity; protease binding; extracellular matrix structural constituent; mercury ion binding

Biological Process: integrin activation; extracellular matrix organization and biogenesis; ossification; wound healing; positive regulation of chemotaxis; positive regulation of axon extension; cell-matrix adhesion; response to glucocorticoid stimulus; glial cell migration; regulation of cell shape; cell activation; response to ozone; acute-phase response; response to wounding; calcium-independent cell-matrix adhesion; cell-substrate junction assembly; angiogenesis; peptide cross-linking; cell adhesion; positive regulation of cell migration; negative regulation of apoptosis