PARP1 Antibody – Rabbit Polyclonal

PARP1: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423. Interacts (when poly-ADP- ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK.

Protein type: EC 2.4.2.30; DNA repair, damage; Transferase; Nucleolus; Nuclear receptor co-regulator; Nuclear envelope

Cellular Component: nucleoplasm; transcription factor complex; protein complex; membrane; cytoplasm; nucleolus; nuclear envelope; nucleus

Molecular Function: identical protein binding; enzyme binding; DNA binding; zinc ion binding; transferase activity, transferring pentosyl groups; protein N-terminus binding; protein kinase binding; transcription factor binding; NAD binding; NAD+ ADP-ribosyltransferase activity

Biological Process: protein autoprocessing; protein amino acid ADP-ribosylation; cellular response to insulin stimulus; transcription, DNA-dependent; base-excision repair; double-strand break repair; transforming growth factor beta receptor signaling pathway; DNA damage response, detection of DNA damage; positive regulation of transcription from RNA polymerase II promoter; regulation of growth rate; telomere maintenance; DNA metabolic process