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TSC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6359388

Acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD]. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TSC2, Polyclonal Antibody
Full Product Name
TSC2, Phosphorylated (T1373) (Tsc2, Tuberin, Tuberous sclerosis 2 protein homolog) (Biotin)
Product Gene Name
Product Synonym Names
Tsc2; Tuberin; Tuberous sclerosis 2 protein homolog
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
194,006 Da
3D Structure
ModBase 3D Structure for P49816
Immunogen
Rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.
Conjugate
Biotin
Antigen Modification
Phosphorylated
Note
Preservative Free

Product Categories/Family for anti-TSC2 antibody

Applications Tested/Suitable for anti-TSC2 antibody
ELISA (EIA), Dot Blot (DB)
Application Notes for anti-TSC2 antibody
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Dot Blot (DB) of anti-TSC2 antibody

Dot blot analysis of rat TSC2 Antibody (Phospho T1373) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
Rabbit Anti-TSC2 Polyclonal Antibody – Cat# MBS6359388

Product References and Citations for anti-TSC2 antibody

Larson, Y., et al. J. Biol. Chem. 285(32):24987-24998(2010). Sajankila, S.P., et al. Mol. Cell. Biochem. 338 (1-2), 233-239 (2010): Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009). Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009). Shiono, M., et al. Oncogene 27(52):6690-6697(2008).

Other Notes

Small volumes of anti-TSC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSC2 purchase

MBS6359388 is an antibody targeting TSC2. Also known as TSC2, Phosphorylated (T1373) (Tsc2, Tuberin, Tuberous sclerosis 2 protein homolog) (Biotin). Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TSC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tuberin
NCBI Official Synonym Full Names
tuberous sclerosis 2
NCBI Official Symbol
Tsc2
NCBI Official Synonym Symbols
Rc
UniProt Protein Name
Tuberin
UniProt Synonym Protein Names
Tuberous sclerosis 2 protein homolog
Protein Family
UniProt Gene Name
Tsc2
UniProt Entry Name
TSC2_RAT
NCBI Protein Information
tuberin

NCBI Summary for TSC2

acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD, Feb 2006]

UniProt Comments for TSC2

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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