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TAFI110 (TAF1C) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8245170

MBS8245170 is an antibody targeting TAF1C. Also known as Anti-TAFI110 Antibody. Reactive in Human, Mouse. Host: Rabbit. Rabbit polyclonal antibody to TAFI110 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TAFI110 (TAF1C), Polyclonal Antibody
Full Product Name
Anti-TAFI110 Antibody
Product Gene Name
anti-TAF1C antibody
Product Synonym Names
TATA box-binding protein-associated factor RNA polymerase I subunit C; RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of TAFI110 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
92,284 Da
OMIM
604905
3D Structure
ModBase 3D Structure for Q15572
Immunogen
Recombinant full length protein of human TAFI110
Applications Tested/Suitable for anti-TAF1C antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TAF1C antibody
WB: 1/500 - 1/2000; IHC: 1/50 - 1/200

Western Blot (WB) of anti-TAF1C antibody

Western blot analysis of TAFI110 expression in HEK293T (A), MCF7 (B), mouse thymus (C) whole cell lysates.
Rabbit Anti-TAF1C Polyclonal Antibody – Cat# MBS8245170

Immunohistochemistry (IHC) of anti-TAF1C antibody

Immunohistochemical analysis of TAFI110 staining in mouse lung formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-TAF1C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS8245170

Other Notes

Small volumes of anti-TAF1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TAF1C. It may not necessarily be applicable to this product.

NCBI GI #
341926281
NCBI GeneID
9013
NCBI Accession #
NP_001230085.1
UniProt Primary Accession #
Q15572
UniProt Secondary Accession #
Q59F67; Q8N6V3; B7Z5K5; B7Z5S4; B7Z908; B7Z9L7
UniProt Related Accession #
Q15572
GenBank Nucleotide #
NM_001243156.1
NCBI Official Full Name
TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 3
NCBI Official Synonym Full Names
TATA-box binding protein associated factor, RNA polymerase I subunit C
NCBI Official Symbol
TAF1C
NCBI Official Synonym Symbols
SL1; TAFI95; TAFI110; MGC:39976
UniProt Protein Name
TATA box-binding protein-associated factor RNA polymerase I subunit C
UniProt Synonym Protein Names
RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C
Protein Family
TATA box-binding protein-associated factor
UniProt Gene Name
TAF1C
UniProt Synonym Gene Names
TAFI110; TBP-associated factor 1C
UniProt Entry Name
TAF1C_HUMAN
NCBI Protein Information
TATA box-binding protein-associated factor RNA polymerase I subunit C

NCBI Summary for TAF1C

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
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UniProt Comments for TAF1C

TAF1C: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; RNA polymerase I transcription factor complex

Molecular Function: protein binding

Biological Process: positive regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter
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Research Articles on TAF1C

1. hCdc14B promotes reactivation of rDNA transcription by dephosphorylating TAFI110. SIRT1 becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68 destabilizing SL1 binding to the rDNA promoter

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TAF1C antibody

 Products by Pathway  Pathway Diagram
 B-WICH Complex Positively Regulates RRNA Expression Pathway antibodies  B-WICH Complex Positively Regulates RRNA Expression Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Negative Epigenetic Regulation Of RRNA Expression Pathway antibodies  Negative Epigenetic Regulation Of RRNA Expression Pathway Diagram
 NoRC Negatively Regulates RRNA Expression Pathway antibodies  NoRC Negatively Regulates RRNA Expression Pathway Diagram
 Positive Epigenetic Regulation Of RRNA Expression Pathway antibodies  Positive Epigenetic Regulation Of RRNA Expression Pathway Diagram
 RNA Polymerase I Chain Elongation Pathway antibodies  RNA Polymerase I Chain Elongation Pathway Diagram
 RNA Polymerase I Promoter Clearance Pathway antibodies  RNA Polymerase I Promoter Clearance Pathway Diagram
 RNA Polymerase I Promoter Escape Pathway antibodies  RNA Polymerase I Promoter Escape Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram

Diseases associated with anti-TAF1C antibody

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >1 publications with TAF1C and Chromosome Aberrations
 Adenocarcinoma Antibodies  >1 publications with TAF1C and Adenocarcinoma
 Hypertrophy Antibodies  >1 publications with TAF1C and Hypertrophy
 Cell Transformation, Neoplastic Antibodies  >1 publications with TAF1C and Cell Transformation, Neoplastic
 Autistic Disorder Antibodies  >1 publications with TAF1C and Autistic Disorder

Organs/Tissues associated with anti-TAF1C antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with TAF1C and Blood
 Bone Antibodies  >1 publications with TAF1C and Bone
 Ovary Antibodies  >1 publications with TAF1C and Ovary
 Thyroid Antibodies  >1 publications with TAF1C and Thyroid
 Stomach Antibodies  >1 publications with TAF1C and Stomach
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