Rabbit Anti-TXN2 Polyclonal Antibody – Cat# MBS821137

Western blot analysis of Thioredoxin 2 expression in HeLa (A), mouse liver (B), H9C2 (C) whole cell lysates.

Thioredoxin 2 (TXN2) Antibody – Rabbit Polyclonal

Name: TXN2 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS821137
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS821137

MBS821137 is an antibody targeting TXN2. Also known as Anti-Thioredoxin 2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to Thioredoxin 2 More details

$225 / 0.03 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thioredoxin 2 (TXN2), Polyclonal Antibody

Full Product Name

Anti-Thioredoxin 2 Antibody

Product Gene Name

anti-TXN2 antibody

Product Synonym Names

TRX2; Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purity/Purification

The antibody was purified by immunogen affinity chromatography.

Specificity

Recognizes endogenous levels of Thioredoxin 2 protein.

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Antibody/Peptide Pairs

Thioredoxin 2 peptide (MBS823986) is used for blocking the activity of Thioredoxin 2 antibody (MBS821137)

Molecular Weight

18,383 Da

OMIM

609063

3D Structure

ModBase 3D Structure for Q99757

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Thioredoxin 2. The exact sequence is proprietary.

Applications Tested/Suitable for anti-TXN2 antibody

Western Blot (WB)

Application Notes for anti-TXN2 antibody

WB (1/500 - 1/1000)

Other Notes

Small volumes of anti-TXN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TXN2. It may not necessarily be applicable to this product.

NCBI GI #

21361403

NCBI GeneID

25828

NCBI Accession #

NP_036605.2

UniProt Primary Accession #

Q99757

UniProt Secondary Accession #

Q5JZA0; Q6FH60; Q9UH29

UniProt Related Accession #

Q99757

GenBank Nucleotide #

NM_012473.3

NCBI Official Full Name

thioredoxin, mitochondrial

NCBI Official Synonym Full Names

thioredoxin 2

NCBI Official Symbol

TXN2

NCBI Official Synonym Symbols

MTRX; TRX2; MT-TRX

UniProt Protein Name

Thioredoxin, mitochondrial

UniProt Synonym Protein Names

Thioredoxin-2

Protein Family

Thioredoxin-like protein

UniProt Gene Name

TXN2

UniProt Synonym Gene Names

TRX2; MTRX; Mt-Trx

UniProt Entry Name

THIOM_HUMAN

NCBI Protein Information

thioredoxin, mitochondrial; thioredoxin-2; mitochondrial thioredoxin

NCBI Summary for TXN2

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

UniProt Comments for TXN2

TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: mitochondrion; cell soma; mitochondrial matrix; dendrite; nucleolus

Molecular Function: peptide-methionine-(S)-S-oxide reductase activity; protein complex binding; protein disulfide oxidoreductase activity; peptide-methionine (R)-S-oxide reductase activity

Biological Process: response to drug; response to reactive oxygen species; cellular response to nutrient levels; cell redox homeostasis; response to glucose stimulus; response to hypoxia; response to hormone stimulus; response to axon injury; response to organic cyclic substance; glycerol ether metabolic process; response to nutrient

Research Articles on TXN2

1. CERKL interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TXN2 antibody

Reference Product	PubMed Publications
TXNRD2 antibody	>9 publications with TXN2 and TXNRD2
TXNRD1 antibody	>8 publications with TXN2 and TXNRD1
SOD1 antibody	>7 publications with TXN2 and SOD1
GLRX3 antibody	>1 publications with TXN2 and GLRX3
TFAM antibody	>1 publications with TXN2 and TFAM

Pathways associated with anti-TXN2 antibody

Products by Pathway	Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Detoxification Of Reactive Oxygen Species Pathway antibodies	Detoxification Of Reactive Oxygen Species Pathway Diagram
Oxidative Stress Pathway antibodies	Oxidative Stress Pathway Diagram

Diseases associated with anti-TXN2 antibody

Disease Name	Pubmed Publications
Death Antibodies	>21 publications with TXN2 and Death
Nervous System Diseases Antibodies	>10 publications with TXN2 and Nervous System Diseases
Brain Diseases Antibodies	>6 publications with TXN2 and Brain Diseases
Disease Models, Animal Antibodies	>6 publications with TXN2 and Disease Models, Animal
Necrosis Antibodies	>5 publications with TXN2 and Necrosis
Liver Diseases Antibodies	>4 publications with TXN2 and Liver Diseases
Inflammation Antibodies	>4 publications with TXN2 and Inflammation
Heart Diseases Antibodies	>3 publications with TXN2 and Heart Diseases
Lung Neoplasms Antibodies	>3 publications with TXN2 and Lung Neoplasms
Fatty Liver Antibodies	>2 publications with TXN2 and Fatty Liver

Organs/Tissues associated with anti-TXN2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>12 publications with TXN2 and Liver
Brain Antibodies	>10 publications with TXN2 and Brain
Vascular Antibodies	>8 publications with TXN2 and Vascular
Heart Antibodies	>7 publications with TXN2 and Heart
Blood Antibodies	>6 publications with TXN2 and Blood
Muscle Antibodies	>6 publications with TXN2 and Muscle
Lung Antibodies	>5 publications with TXN2 and Lung
Eye Antibodies	>5 publications with TXN2 and Eye
Nerve Antibodies	>4 publications with TXN2 and Nerve
Kidney Antibodies	>3 publications with TXN2 and Kidney