CXCR3 Positive Control

Name: CXCR3 Positive Control; MyBioSource
Brand: MyBioSource
SKU: MBS542665
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS542665

MBS542665 is a positive control targeting CXCR3. Also known as CXCR3 Antibody Western Blot Positive Control. Western Blot Positive Control IP10 Receptor Antibody More details

$370 / 5 Applications +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CXCR3, Positive Control

Full Product Name

CXCR3 Antibody Western Blot Positive Control

Product Gene Name

CXCR3 positive control

Product Synonym Names

C-X-C chemokine receptor type 3; CD 183; CD182; Chemokine CXC Motif Receptor 3; CKR L2; CKR-L2; CMKAR3; CXC-R3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; Mig R; Mig receptor antibody

Form/Format

Western Blot Positive Control

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: CXCR3 (MBS541345)
Positive Control: CXCR3 (MBS542665)

Matching Pairs

Antibody: CXCR3 (MBS541346)
Positive Control: CXCR3 (MBS542665)

Molecular Weight

28,715 Da

OMIM

300574

3D Structure

ModBase 3D Structure for P49682

Immunogen

Purified Protein

Expression

Isoforms 1 and 2 are expressed mainly in the heart, kidney, liver and skeletal muscle. Isoform 1 is additionally found in placenta, and Isoform 2 is also expressed in endothelial cells. At protein level, expression is present in T-cells.

Molecular Function

G-protein coupled receptor, Transducer, chemokine binding

Structure

Homomer, forms heteromers with ACKR7

Subcellular Location

Cell membrane; Multipass membrane protein

Applications Tested/Suitable for CXCR3 positive control

Western Blot (WB)

Application Notes for CXCR3 positive control

Western Blot: 1:500

Other Notes

Small volumes of CXCR3 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.

NCBI GI #

4504099

NCBI GeneID

2833

NCBI Accession #

NP_001495

UniProt Primary Accession #

P49682

UniProt Secondary Accession #

O15185; Q7Z710; Q9P2T4; Q9P2T5; B2R982

UniProt Related Accession #

P49682

GenBank Nucleotide #

NM_001504.1

NCBI Official Full Name

C-X-C chemokine receptor type 3 isoform 1

NCBI Official Synonym Full Names

C-X-C motif chemokine receptor 3

NCBI Official Symbol

CXCR3

NCBI Official Synonym Symbols

GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R

UniProt Protein Name

C-X-C chemokine receptor type 3

UniProt Synonym Protein Names

CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183

Protein Family

C-X-C chemokine receptor

UniProt Gene Name

CXCR3

UniProt Synonym Gene Names

GPR9; CXC-R3; CXCR-3; IP-10 receptor

UniProt Entry Name

CXCR3_HUMAN

NCBI Protein Information

C-X-C chemokine receptor type 3

NCBI Summary for CXCR3

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

UniProt Comments for CXCR3

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: cytoplasm; cytosol; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; chemokine binding; chemokine receptor activity; receptor activity

Biological Process: angiogenesis; apoptosis; calcium-mediated signaling; cell adhesion; cell motility; cell surface receptor linked signal transduction; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of angiogenesis; positive regulation of cAMP metabolic process; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of leukocyte migration

Research Articles on CXCR3

1. The expression of the chemokine receptors CXCR3, CXCR4 and CXCR7 and their ligands.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCR3 positive control

Reference Product	PubMed Publications
CXCL10 positive control	>962 publications with CXCR3 and CXCL10
CXCL9 positive control	>545 publications with CXCR3 and CXCL9
CXCL11 positive control	>356 publications with CXCR3 and CXCL11
CCL5 positive control	>169 publications with CXCR3 and CCL5
CXCL12 positive control	>140 publications with CXCR3 and CXCL12
CCL21 positive control	>54 publications with CXCR3 and CCL21
CXCL13 positive control	>32 publications with CXCR3 and CXCL13
CCL19 positive control	>30 publications with CXCR3 and CCL19
CCL11 positive control	>27 publications with CXCR3 and CCL11
PF4 positive control	>14 publications with CXCR3 and PF4

Pathways associated with CXCR3 positive control

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with CXCR3 positive control

Disease Name	Pubmed Publications
Inflammation Antibodies	>655 publications with CXCR3 and Inflammation
Autoimmune Diseases Antibodies	>348 publications with CXCR3 and Autoimmune Diseases
Necrosis Antibodies	>224 publications with CXCR3 and Necrosis
Lung Diseases Antibodies	>199 publications with CXCR3 and Lung Diseases
Hypersensitivity Antibodies	>146 publications with CXCR3 and Hypersensitivity
Liver Diseases Antibodies	>139 publications with CXCR3 and Liver Diseases
Carcinoma Antibodies	>121 publications with CXCR3 and Carcinoma
Cardiovascular Diseases Antibodies	>109 publications with CXCR3 and Cardiovascular Diseases
Death Antibodies	>90 publications with CXCR3 and Death
Fibrosis Antibodies	>90 publications with CXCR3 and Fibrosis

Organs/Tissues associated with CXCR3 positive control

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1654 publications with CXCR3 and Blood
Brain Antibodies	>154 publications with CXCR3 and Brain
Spleen Antibodies	>132 publications with CXCR3 and Spleen
Intestine Antibodies	>78 publications with CXCR3 and Intestine
Muscle Antibodies	>68 publications with CXCR3 and Muscle
Connective Tissue Antibodies	>18 publications with CXCR3 and Connective Tissue
Uncharacterized Tissue Antibodies	>2 publications with CXCR3 and Uncharacterized Tissue