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GRK6 Positive Control

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5400708

Overview: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to… More details

$370 / 5 Applications +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRK6, Positive Control
Full Product Name
GRK6 Positive Control
Product Gene Name
Product Synonym Names
Western Blot Positive Control G protein-coupled receptor kinase 6; G protein coupled receptor kinase 6 antibody; G protein coupled receptor kinase GRK6 antibody; Gprk6 antibody; Grk6 antibody
Preparation and Storage
Store at -20 degree C for long term storage.
Molecular Weight
64,294 Da
3D Structure
ModBase 3D Structure for P43250
Immunogen
Purified Protein
Molecular Function
ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity
Subcellular Location
Membrane; Lipid-anchor
Applications Tested/Suitable for GRK6 positive control
Western Blot (WB)
Application Notes for GRK6 positive control
WB: 1:2,500-1:5,000

Other Notes

Small volumes of GRK6 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRK6 purchase

MBS5400708 is a positive control targeting GRK6.

Additional Details

NCBI/Uniprot data below describe general gene information for GRK6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
G protein-coupled receptor kinase 6 isoform B
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 6
NCBI Official Symbol
GRK6
NCBI Official Synonym Symbols
GPRK6
UniProt Protein Name
G protein-coupled receptor kinase 6
UniProt Synonym Protein Names
G protein-coupled receptor kinase GRK6
UniProt Gene Name
GRK6
UniProt Synonym Gene Names
GPRK6
NCBI Protein Information
G protein-coupled receptor kinase 6

NCBI Summary for GRK6

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GRK6

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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