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PDE3B Positive Control – Phospho

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS543152

Western Blot Positive Control Phosphorylated Phosphodiesterase 3BCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat… More details

$385 / 5 Applications +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Phospho-PDE3B, Positive Control
Full Product Name
Phospho-PDE3B Antibody Positive Control
Product Gene Name
PDE3B positive control
Product Synonym Names
5''-cyclic phosphodiesterase B; Adipocyte cAMP phosphodiesterase cGMP inhibited; AI847709; cAMP Phosphodiesterase, adipocyte, cGMP-inhibited; CGI-PDE B; CGIP1; CGIPDE1; cGMP inhibited 3 5 cyclic phosphodiesterase B; HcGIP1; Pde3b; Phosphodiesterase 3B cGMP inhibited antibody
Form/Format
Western Blot Positive Control
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: Phospho-PDE3B (MBS540783)
Positive Control: Phospho-PDE3B (MBS543152)
Matching Pairs
Antibody: Phospho-PDE3B (MBS540874)
Positive Control: Phospho-PDE3B (MBS543152)
Molecular Weight
118,809 Da
OMIM
602047
3D Structure
ModBase 3D Structure for Q13370
Immunogen
Purified Protein
Expression
Abundant in adipose tissues.
Modification
Phosphorylated
Molecular Function
Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Structure
Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6 (By similarity).
Subcellular Location
Membrane; Multipass membrane protein
Applications Tested/Suitable for PDE3B positive control
Western Blot (WB)
Application Notes for PDE3B positive control
Western Blot: 1:500

Other Notes

Small volumes of PDE3B positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE3B purchase

MBS543152 is a positive control targeting PDE3B. Also known as Phospho-PDE3B Antibody Positive Control.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE3B. It may not necessarily be applicable to this product.

NCBI GI #
149068220
NCBI GeneID
29516
NCBI Accession #
EDM17772.1
UniProt Primary Accession #
Q13370
UniProt Secondary Accession #
O00639; Q14408; Q6SEI4; B7ZM37
UniProt Related Accession #
Q63085
NCBI Official Full Name
phosphodiesterase 3B, isoform CRA_a
NCBI Official Synonym Full Names
phosphodiesterase 3B
NCBI Official Symbol
Pde3b
UniProt Protein Name
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
UniProt Synonym Protein Names
CGIPDE1; CGIP1; Cyclic GMP-inhibited phosphodiesterase B; CGI-PDE B
Protein Family
cGMP-inhibited 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE3B
UniProt Synonym Gene Names
CGIP1; CGI-PDE B
UniProt Entry Name
PDE3B_HUMAN
NCBI Protein Information
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

NCBI Summary for PDE3B

catalyzes the hydrolysis of cAMP and cGMP; regulates insulin secretory processes [RGD, Feb 2006]

UniProt Comments for PDE3B

PDE3B: a cGMP-inhibited phosphodiesterase 1 involved in fat metabolism. Inhibition of PDE3B can augment PDE4 inhibitor-induced apoptosis in some patients with chronic lymphocytic leukemia.

Protein type: EC 3.1.4.17; Nucleotide Metabolism - purine; Membrane protein, multi-pass; Membrane protein, integral; Phosphodiesterase

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytosol; endoplasmic reticulum; Golgi apparatus; integral to membrane; membrane

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein binding; protein kinase B binding

Biological Process: angiogenesis; cAMP catabolic process; cellular response to insulin stimulus; negative regulation of angiogenesis; negative regulation of cell adhesion; negative regulation of cell adhesion mediated by integrin; negative regulation of lipid catabolic process; signal transduction
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Research Articles on PDE3B

1. C-peptide has the potential to act, conditionally, as an antilipolytic hormone by activating phosphodiesterase-3B.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PDE3B positive control

 Products by Pathway  Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Triggered By IGF1R Pathway antibodies  IRS-related Events Triggered By IGF1R Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram

Diseases associated with PDE3B positive control

 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >17 publications with PDE3B and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >14 publications with PDE3B and Cardiovascular Diseases
 Necrosis Antibodies  >12 publications with PDE3B and Necrosis
 Disease Models, Animal Antibodies  >11 publications with PDE3B and Disease Models, Animal
 Fatty Liver Antibodies  >7 publications with PDE3B and Fatty Liver
 Heart Diseases Antibodies  >6 publications with PDE3B and Heart Diseases
 Inflammation Antibodies  >6 publications with PDE3B and Inflammation
 Lung Diseases Antibodies  >5 publications with PDE3B and Lung Diseases
 Hypertension Antibodies  >4 publications with PDE3B and Hypertension
 Brain Diseases Antibodies  >3 publications with PDE3B and Brain Diseases

Organs/Tissues associated with PDE3B positive control

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with PDE3B and Blood
 Muscle Antibodies  >41 publications with PDE3B and Muscle
 Heart Antibodies  >34 publications with PDE3B and Heart
 Vascular Antibodies  >28 publications with PDE3B and Vascular
 Liver Antibodies  >20 publications with PDE3B and Liver
 Pancreas Antibodies  >19 publications with PDE3B and Pancreas
 Brain Antibodies  >18 publications with PDE3B and Brain
 Connective Tissue Antibodies  >17 publications with PDE3B and Connective Tissue
 Lung Antibodies  >12 publications with PDE3B and Lung
 Kidney Antibodies  >8 publications with PDE3B and Kidney
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