PINK1 Positive Control

PINK1: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Membrane protein, integral; Other group; NKF2 family

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: axon; chromatin; cytoplasm; cytoskeleton; cytosol; integral to mitochondrial outer membrane; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion; nucleus; perinuclear region of cytoplasm; TORC2 complex; ubiquitin ligase complex

Molecular Function: ATP binding; kinase activity; magnesium ion binding; protease activator activity; protease binding; protein binding; protein kinase activity; protein kinase B binding; protein serine/threonine kinase activity; ubiquitin protein ligase binding

Biological Process: activation of protein kinase B; macroautophagy; mitochondrion degradation; mitochondrion organization and biogenesis; negative regulation of JNK cascade; negative regulation of macroautophagy; negative regulation of neuron apoptosis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of dopamine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of macroautophagy; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid dephosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of synaptic transmission, dopaminergic; positive regulation of transcription factor activity; positive regulation of translation; positive regulation of ubiquitin-protein ligase activity; protein amino acid phosphorylation; protein stabilization; protein ubiquitination; regulation of hydrogen peroxide metabolic process; regulation of mitochondrial membrane potential; regulation of oxidative phosphorylation; regulation of protein complex assembly; regulation of protein ubiquitination; response to oxidative stress; response to stress; ubiquitin-dependent protein catabolic process

Disease: Parkinson Disease 6, Autosomal Recessive Early-onset