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ULK3 Positive Control

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS543368

Western Blot Positive Control Serine/Threonine-protein kinase ULK3Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts… More details

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Product Overview

Online Datasheet in PDF
Product Name
ULK3, Positive Control
Full Product Name
ULK3 Positive Control
Product Gene Name
ULK3 positive control
Product Synonym Names
DKFZP434C131; FLJ90566; Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3 antibody
Form/Format
Western Blot Positive Control
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: ULK3 (MBS540668)
Positive Control: ULK3 (MBS543368)
Matching Pairs
Antibody: ULK3 (MBS5400210)
Positive Control: ULK3 (MBS543368)
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Molecular Weight
53,419 Da
3D Structure
ModBase 3D Structure for D3ZHP7
Immunogen
Purified Protein
Expression
Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.
Molecular Function
ATP-binding; Nucleotide-binding; Serine/threonine-protein kinase
Structure
Interacts (via protein kinase domain) with SUFU.
Subcellular Location
Cytoplasm
Applications Tested/Suitable for ULK3 positive control
Western Blot (WB)
Application Notes for ULK3 positive control
Western Blot: 1:500

Other Notes

Small volumes of ULK3 positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ULK3 purchase

MBS543368 is a positive control targeting ULK3.

Additional Details

NCBI/Uniprot data below describe general gene information for ULK3. It may not necessarily be applicable to this product.

NCBI GI #
402794783
NCBI GeneID
691171
NCBI Accession #
NP_001258064.1
UniProt Primary Accession #
D3ZHP7
UniProt Related Accession #
D3ZHP7
GenBank Nucleotide #
NM_001271135.1
NCBI Official Full Name
serine/threonine-protein kinase ULK3
NCBI Official Synonym Full Names
unc-51 like kinase 3
NCBI Official Symbol
Ulk3
UniProt Protein Name
Serine/threonine-protein kinase ULK3
UniProt Synonym Protein Names
Unc-51-like kinase 3
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
Ulk3
UniProt Entry Name
ULK3_RAT
NCBI Protein Information
serine/threonine-protein kinase ULK3

UniProt Comments for ULK3

ULK3: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; ULK family

Cellular Component: cytoplasm

Molecular Function: ATP binding; protein serine/threonine kinase activity

Biological Process: autophagy; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; protein amino acid autophosphorylation
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Research Articles on ULK3

1. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ULK3 positive control

 Products by Pathway  Pathway Diagram
 Hedgehog 'on' State Pathway antibodies  Hedgehog 'on' State Pathway Diagram
 Longevity Regulating Pathway antibodies  Longevity Regulating Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hedgehog Pathway antibodies  Signaling By Hedgehog Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with ULK3 positive control

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >8 publications with ULK3 and Hypertension
 Vascular Diseases Antibodies  >5 publications with ULK3 and Vascular Diseases
 Brain Diseases Antibodies  >2 publications with ULK3 and Brain Diseases
 Mental Disorders Antibodies  >1 publications with ULK3 and Mental Disorders

Organs/Tissues associated with ULK3 positive control

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with ULK3 and Brain
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