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Prolactin (PRL) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844215

Background: Prolactin (also known as mammotrophin, luterotropic hormone, and lutetropin) is a neuroendocrine hormone secreted by the pituitary gland. Its primary function is to promote and maintain lactation during pregnancy and suckling. In addition,… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Prolactin (PRL), Active Protein
Full Product Name
Prolactin, human recombinant
Product Gene Name
PRL active protein
Product Synonym Names
Mammotropin; Luterotropic hormone; Lutetropin; Prlr; PRL; luteotropic hormone; LTH; PRLR; PRL-R; PRL R
Host
E Coli
Form/Format
Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 8.0 + 50 mM NaCl.
Appearance: Lyophilized protein
Purity/Purification
>=95%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
23.3 kDa
OMIM
176760
3D Structure
ModBase 3D Structure for P01236
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
The ED?? determined by the dose-dependent stimulation of the proliferation of rat lymphoma, Nb2-11 cells was found to be <0.065 ng/ml.
Results
<0.065 ng/ml
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for PRL active protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z)
Applications Tested/Suitable for PRL active protein
SDS-PAGE; HPLC

Other Notes

Small volumes of PRL active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRL purchase

MBS844215 is an active protein targeting PRL. Also known as Prolactin, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PRL. It may not necessarily be applicable to this product.

NCBI GI #
4506105
NCBI GeneID
5617
NCBI Accession #
NP_000939.1
UniProt Primary Accession #
P01236
UniProt Secondary Accession #
Q15199; Q92996
UniProt Related Accession #
P01236
GenBank Nucleotide #
NM_000948.5
NCBI Official Full Name
prolactin
NCBI Official Synonym Full Names
prolactin
NCBI Official Symbol
PRL
UniProt Protein Name
Prolactin
Protein Family
Prolactin
UniProt Gene Name
PRL
UniProt Synonym Gene Names
PRL
UniProt Entry Name
PRL_HUMAN
NCBI Protein Information
prolactin

NCBI Summary for PRL

This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
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UniProt Comments for PRL

prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.

Protein type: Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: extracellular region

Molecular Function: protein binding; prolactin receptor binding; hormone activity

Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; positive regulation of JAK-STAT cascade; regulation of multicellular organism growth; female pregnancy
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Research Articles on PRL

1. serum levels were found to be higher in the infertile women than in controls

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PRL active protein

 Reference Product  PubMed Publications
 TRH active protein  >1760 publications with PRL and TRH
 PRLR active protein  >362 publications with PRL and PRLR
 JAK2 active protein  >191 publications with PRL and JAK2
 POU1F1 active protein  >141 publications with PRL and POU1F1
 STAT5A active protein  >82 publications with PRL and STAT5A
 STAT3 active protein  >63 publications with PRL and STAT3
 GHR active protein  >52 publications with PRL and GHR
 STAT5B active protein  >48 publications with PRL and STAT5B
 ESR1 active protein  >12 publications with PRL and ESR1
 BMP1 active protein  >2 publications with PRL and BMP1

Pathways associated with PRL active protein

 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with PRL active protein

 Disease Name  Pubmed Publications
 Pituitary Neoplasms Antibodies  >2041 publications with PRL and Pituitary Neoplasms
 Hyperprolactinemia Antibodies  >1535 publications with PRL and Hyperprolactinemia
 Adenoma Antibodies  >1503 publications with PRL and Adenoma
 Prolactinoma Antibodies  >688 publications with PRL and Prolactinoma
 Mental Disorders Antibodies  >610 publications with PRL and Mental Disorders
 Amenorrhea Antibodies  >428 publications with PRL and Amenorrhea
 Galactorrhea Antibodies  >319 publications with PRL and Galactorrhea
 Growth Hormone-Secreting Pituitary Adenoma Antibodies  >265 publications with PRL and Growth Hormone-Secreting Pituitary Adenoma
 Infertility, Female Antibodies  >243 publications with PRL and Infertility, Female
 Hypogonadism Antibodies  >209 publications with PRL and Hypogonadism

Organs/Tissues associated with PRL active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5156 publications with PRL and Brain
 Pituitary Gland Antibodies  >4001 publications with PRL and Pituitary Gland
 Uterus Antibodies  >525 publications with PRL and Uterus
 Testis Antibodies  >500 publications with PRL and Testis
 Placenta Antibodies  >394 publications with PRL and Placenta
 Heart Antibodies  >211 publications with PRL and Heart
 Eye Antibodies  >199 publications with PRL and Eye
 Muscle Antibodies  >194 publications with PRL and Muscle
 Connective Tissue Antibodies  >122 publications with PRL and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with PRL and Uncharacterized Tissue
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