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ANAPC15 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9417284

ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic… More details

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Product Overview

Online Datasheet in PDF
Product Name
ANAPC15, Polyclonal Antibody
Full Product Name
ANAPC15 Antibody
Product Gene Name
anti-ANAPC15 antibody
Product Synonym Names
APC15; HSPC020; C11orf51
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Purity/Purification
Antigen affinity purification
Concentration
1.2mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total ANAPC15 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
14,716 Da
OMIM
AF077206 mRNA
3D Structure
ModBase 3D Structure for P60006
Immunogen
Synthetic peptide of human ANAPC15
Immunogen Type
Peptide

Product Categories/Family for anti-ANAPC15 antibody

Total protein Ab
Applications Tested/Suitable for anti-ANAPC15 antibody
Immunohistochemistry (IHC)
Application Notes for anti-ANAPC15 antibody
Immunohistochemistry: 1: 30-150

Immunohistochemistry (IHC) of anti-ANAPC15 antibody

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ANAPC15 Antibody at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200)
Rabbit Anti-ANAPC15 Polyclonal Antibody – Cat# MBS9417284

Immunohistochemistry (IHC) of anti-ANAPC15 antibody

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using ANAPC15 Antibody at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200)
Rabbit Anti-ANAPC15 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9417284

Other Notes

Small volumes of anti-ANAPC15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANAPC15 purchase

MBS9417284 is an antibody targeting ANAPC15. Also known as ANAPC15 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANAPC15. It may not necessarily be applicable to this product.

NCBI GI #
511094008
NCBI GeneID
25906
NCBI Accession #
NP_001265414.1
UniProt Primary Accession #
P60006
UniProt Secondary Accession #
Q9CXK2; Q9Y269; G3V1Q3
UniProt Related Accession #
P60006
GenBank Nucleotide #
NM_001278485.1
NCBI Official Full Name
anaphase-promoting complex subunit 15 isoform a
NCBI Official Synonym Full Names
anaphase promoting complex subunit 15
NCBI Official Symbol
ANAPC15
NCBI Official Synonym Symbols
APC15; HSPC020; C11orf51
UniProt Protein Name
Anaphase-promoting complex subunit 15
UniProt Gene Name
ANAPC15
UniProt Synonym Gene Names
C11orf51; APC15
UniProt Entry Name
APC15_HUMAN
NCBI Protein Information
anaphase-promoting complex subunit 15

UniProt Comments for ANAPC15

APC15: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. Belongs to the APC15 family.

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: anaphase-promoting complex; cytosol; intracellular; nucleoplasm

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
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Research Articles on ANAPC15

1. Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 and mitotic checkpoint protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ANAPC15 antibody

 Products by Pathway  Pathway Diagram
 APC-Cdc20 Mediated Degradation Of Nek2A Pathway antibodies  APC-Cdc20 Mediated Degradation Of Nek2A Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Autodegradation Of Cdh1 By Cdh1:APC/C Pathway antibodies  Autodegradation Of Cdh1 By Cdh1:APC/C Pathway Diagram
 Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway antibodies  Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway Diagram
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