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KCNS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7045025

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328).… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KCNS3, Polyclonal Antibody
Full Product Name
KCNS3 Antibody
Product Gene Name
anti-KCNS3 antibody
Product Synonym Names
Potassium voltage-gated channel subfamily S member 3; Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3; KCNS3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
56,001 Da
OMIM
603888
3D Structure
ModBase 3D Structure for Q9BQ31
Species
Human
Immunogen
Recombinant human Potassium voltage-gated channel subfamily S member 3 protein (N-180AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-51127
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KCNS3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-KCNS3 antibody

Western blot
All lanes: KCNS3 antibody at 6.35 ug/ml+ Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56 kDa
Observed band size: 56,35 kDa
Rabbit Anti-KCNS3 Polyclonal Antibody – Cat# MBS7045025

Immunohistochemistry (IHC) of anti-KCNS3 antibody

Immunohistochemistry of paraffin-embedded human lung tissue using MBS7045025 at dilution 1:100
Rabbit Anti-KCNS3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7045025

Immunohistochemistry (IHC) of anti-KCNS3 antibody

Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7045025 at dilution 1:100
Rabbit Anti-KCNS3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7045025

Other Notes

Small volumes of anti-KCNS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNS3 purchase

MBS7045025 is an antibody targeting KCNS3. Also known as KCNS3 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNS3. It may not necessarily be applicable to this product.

NCBI GI #
539846921
NCBI GeneID
3790
NCBI Accession #
NP_001269357.1
UniProt Primary Accession #
Q9BQ31
UniProt Secondary Accession #
O43651; Q4ZFY1; Q96B56; D6W520
UniProt Related Accession #
Q9BQ31
GenBank Nucleotide #
NM_001282428.1
NCBI Official Full Name
potassium voltage-gated channel subfamily S member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel modifier subfamily S member 3
NCBI Official Symbol
KCNS3
NCBI Official Synonym Symbols
KV9.3
UniProt Protein Name
Potassium voltage-gated channel subfamily S member 3
UniProt Synonym Protein Names
Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNS3
UniProt Entry Name
KCNS3_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily S member 3

NCBI Summary for KCNS3

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
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UniProt Comments for KCNS3

Kv9.3: Potassium channel subunit. Modulates channel activity and reduces the ion flow. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p24

Cellular Component: cytoplasm; Golgi apparatus; integral to membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity

Biological Process: potassium ion transport; regulation of insulin secretion
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Research Articles on KCNS3

1. By in situ hybridization, KCNS3 mRNA levels were 23% lower in schizophrenia subjects than in controls. At the cellular level, both KCNS3 mRNA-expressing neuron density and KCNS3 mRNA level per neuron were significantly lower.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KCNS3 antibody

 Products by Pathway  Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNS3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with KCNS3 and Nervous System Diseases
 Hypertension Antibodies  >1 publications with KCNS3 and Hypertension
 Cardiovascular Diseases Antibodies  >1 publications with KCNS3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with KCNS3 and Heart Diseases

Organs/Tissues associated with anti-KCNS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with KCNS3 and Brain
 Lung Antibodies  >3 publications with KCNS3 and Lung
 Vascular Antibodies  >2 publications with KCNS3 and Vascular
 Heart Antibodies  >2 publications with KCNS3 and Heart
 Muscle Antibodies  >2 publications with KCNS3 and Muscle
 Bone Antibodies  >1 publications with KCNS3 and Bone
 Placenta Antibodies  >1 publications with KCNS3 and Placenta
 Embryonic Tissue Antibodies  >1 publications with KCNS3 and Embryonic Tissue
 Kidney Antibodies  >1 publications with KCNS3 and Kidney
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