5HT7R Human Protein

Name: 5HT7R Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS189923
Price: 1320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS189923

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement… More details

$1320 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

5HT7R, Protein

Full Product Name

Human 5HT7R full length protein-synthetic nanodisc

Product Gene Name

5HT7R protein

Product Synonym Names

5-HT7

Host

HEK293

Form/Format

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).

Molecular Weight

53,555 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (92500575..92617671, complement). Location: 10q21-q24

OMIM

182137

3D Structure

ModBase 3D Structure for P34969

Product Categories/Family for 5HT7R protein

FLP 489; Full Length Transmembrane Proteins

Other Notes

Small volumes of 5HT7R protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 5HT7R purchase

MBS189923 is a protein targeting 5HT7R. Also known as Human 5HT7R full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for 5HT7R. It may not necessarily be applicable to this product.

NCBI GI #

4504547

NCBI GeneID

3363

NCBI Accession #

NP_000863.1

UniProt Primary Accession #

P34969

UniProt Secondary Accession #

P78336; P78372; P78516; Q5VX01; Q5VX02; Q5VX03; B5BUP6

UniProt Related Accession #

P34969

GenBank Nucleotide #

NM_000872.4

NCBI Official Full Name

5-hydroxytryptamine receptor 7 isoform a

NCBI Official Synonym Full Names

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled

NCBI Official Symbol

HTR7

NCBI Official Synonym Symbols

5-HT7

UniProt Protein Name

5-hydroxytryptamine receptor 7

UniProt Synonym Protein Names

5-HT-X; Serotonin receptor 7

UniProt Gene Name

HTR7

UniProt Synonym Gene Names

5-HT-7; 5-HT7

UniProt Entry Name

5HT7R_HUMAN

NCBI Protein Information

5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

UniProt Comments for 5HT7R

5-HT(7): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q21-q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: serotonin receptor activity

Biological Process: circadian rhythm; vasoconstriction; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; smooth muscle contraction; blood circulation; serotonin receptor signaling pathway

Research Articles on 5HT7R

1. Serotonin skews human macrophage polarization through HTR2B and HTR7.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with 5HT7R protein

Products by Pathway	Pathway Diagram
Amine Ligand-binding Receptors Pathway antibodies	Amine Ligand-binding Receptors Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Monoamine GPCRs Pathway antibodies	Monoamine GPCRs Pathway Diagram

Diseases associated with 5HT7R protein

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>13 publications with 5HT7R and Mental Disorders
Nervous System Diseases Antibodies	>5 publications with 5HT7R and Nervous System Diseases
Schizophrenia Antibodies	>5 publications with 5HT7R and Schizophrenia
Inflammation Antibodies	>4 publications with 5HT7R and Inflammation
Disease Models, Animal Antibodies	>3 publications with 5HT7R and Disease Models, Animal
Brain Diseases Antibodies	>3 publications with 5HT7R and Brain Diseases
Muscular Diseases Antibodies	>2 publications with 5HT7R and Muscular Diseases
Mood Disorders Antibodies	>2 publications with 5HT7R and Mood Disorders
Pain Antibodies	>2 publications with 5HT7R and Pain
Drug Toxicity Antibodies	>1 publications with 5HT7R and Drug Toxicity

Organs/Tissues associated with 5HT7R protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with 5HT7R and Brain