• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CAC1D Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1883076

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium… More details

$1320 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAC1D, Protein
Full Product Name
Human CAC1D full length protein-synthetic nanodisc
Product Gene Name
CAC1D protein
Product Synonym Names
CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3; PASNA; SANDD
Host
HEK293
Form/Format
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Molecular Weight
242,417 Da
OMIM
615474
3D Structure
ModBase 3D Structure for Q01668
Tag
C-DYKDDDDK

Product Categories/Family for CAC1D protein

Full Length Transmembrane Proteins; Ion Channels: Calcium

Other Notes

Small volumes of CAC1D protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAC1D purchase

MBS1883076 is a protein targeting CAC1D. Also known as Human CAC1D full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for CAC1D. It may not necessarily be applicable to this product.

NCBI GI #
116241275
NCBI GeneID
776
NCBI Accession #
Q01668.2
UniProt Primary Accession #
Q01668
UniProt Secondary Accession #
Q13916; Q13931; Q71UT1; Q9UDC3; B0FYA3
UniProt Related Accession #
Q01668
NCBI Official Full Name
Voltage-dependent L-type calcium channel subunit alpha-1D
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, L type, alpha 1D subunit
NCBI Official Symbol
CACNA1D
NCBI Official Synonym Symbols
CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt Synonym Protein Names
Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3
UniProt Gene Name
CACNA1D
UniProt Synonym Gene Names
CACH3; CACN4; CACNL1A2; CCHL1A2
UniProt Entry Name
CAC1D_HUMAN
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-ty

UniProt Comments for CAC1D

CACNA1D: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: plasma membrane; voltage-gated calcium channel complex; Z disc

Molecular Function: voltage-gated calcium channel activity; metal ion binding; high voltage-gated calcium channel activity; ankyrin binding; alpha-actinin binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; axon guidance; sensory perception of sound; calcium ion transport; energy reserve metabolic process; positive regulation of calcium ion transport; regulation of insulin secretion

Disease: Primary Aldosteronism, Seizures, And Neurologic Abnormalities; Sinoatrial Node Dysfunction And Deafness
Show more

Research Articles on CAC1D

1. in patients with aldosterone-producing adenomas, CACNA1D mutations were associated with smaller adenomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CAC1D protein

 Reference Product  PubMed Publications
 CACNB2 protein  >4 publications with CAC1D and CACNB2
 CACNA2D1 protein  >4 publications with CAC1D and CACNA2D1
 CACNB4 protein  >1 publications with CAC1D and CACNB4

Pathways associated with CAC1D protein

 Products by Pathway  Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram

Diseases associated with CAC1D protein

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >16 publications with CAC1D and Disease Models, Animal
 Deafness Antibodies  >14 publications with CAC1D and Deafness
 Hypertension Antibodies  >13 publications with CAC1D and Hypertension
 Brain Diseases Antibodies  >11 publications with CAC1D and Brain Diseases
 Heart Diseases Antibodies  >10 publications with CAC1D and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >10 publications with CAC1D and Arrhythmias, Cardiac
 Adenoma Antibodies  >10 publications with CAC1D and Adenoma
 Hyperaldosteronism Antibodies  >8 publications with CAC1D and Hyperaldosteronism
 Bradycardia Antibodies  >8 publications with CAC1D and Bradycardia
 Pain Antibodies  >5 publications with CAC1D and Pain

Organs/Tissues associated with CAC1D protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >81 publications with CAC1D and Brain
 Heart Antibodies  >30 publications with CAC1D and Heart
 Muscle Antibodies  >28 publications with CAC1D and Muscle
 Pancreas Antibodies  >12 publications with CAC1D and Pancreas
 Eye Antibodies  >10 publications with CAC1D and Eye
 Kidney Antibodies  >6 publications with CAC1D and Kidney
 Bone Antibodies  >5 publications with CAC1D and Bone
 Adrenal Gland Antibodies  >3 publications with CAC1D and Adrenal Gland
 Intestine Antibodies  >3 publications with CAC1D and Intestine
 Prostate Antibodies  >3 publications with CAC1D and Prostate
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000