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CACB2 Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1883667

This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CACB2, Protein
Full Product Name
Human CACB2-Strep full length protein-synthetic nanodisc
Product Gene Name
CACB2 protein
Product Synonym Names
CAB2; CACNLB2; CAVB2; MYSB
Host
HEK293
Form/Format
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Molecular Weight
65,658 Da
OMIM
600003
3D Structure
ModBase 3D Structure for Q08289
Tag
C-DYKDDDDK&Strep

Product Categories/Family for CACB2 protein

Full Length Transmembrane Proteins; Ion Channels: Other

Other Notes

Small volumes of CACB2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACB2 purchase

MBS1883667 is a protein targeting CACB2. Also known as Human CACB2-Strep full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for CACB2. It may not necessarily be applicable to this product.

NCBI GI #
148232726
NCBI GeneID
783
NCBI Accession #
NP_000715
UniProt Primary Accession #
Q08289
UniProt Secondary Accession #
O00304; Q5QJ99; Q5QJA0; Q5VVG9; Q5VVH0; Q5VWV6; Q6TME1; Q6TME2; A6PVM5; A6PVM7; A6PVM8
UniProt Related Accession #
Q08289; AAB27916
GenBank Nucleotide #
NM_000724.3
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2 isoform 1
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, beta 2 subunit
NCBI Official Symbol
CACNB2
NCBI Official Synonym Symbols
MYSB; CAVB2; CACNLB2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-2
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB
UniProt Gene Name
CACNB2
UniProt Synonym Gene Names
CACNLB2; MYSB; CAB2; MYSB
UniProt Entry Name
CACB2_HUMAN
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2

UniProt Comments for CACB2

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: integral to plasma membrane; voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium channel activity; high voltage-gated calcium channel activity

Biological Process: synaptic transmission; axon guidance; visual perception; transport; positive regulation of calcium ion transport; neuromuscular junction development

Disease: Brugada Syndrome 4
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Research Articles on CACB2

1. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CACB2 protein

 Reference Product  PubMed Publications
 CACNA1C protein  >32 publications with CACB2 and CACNA1C
 CACNA2D1 protein  >7 publications with CACB2 and CACNA2D1
 CACNA1D protein  >4 publications with CACB2 and CACNA1D
 CACNB3 protein  >3 publications with CACB2 and CACNB3
 CACNA1I protein  >2 publications with CACB2 and CACNA1I
 CACNA1G protein  >2 publications with CACB2 and CACNA1G
 CACNA1S protein  >1 publications with CACB2 and CACNA1S

Pathways associated with CACB2 protein

 Products by Pathway  Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram

Diseases associated with CACB2 protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >29 publications with CACB2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >11 publications with CACB2 and Nervous System Diseases
 Brugada Syndrome 4 Antibodies  >5 publications with CACB2 and Brugada Syndrome 4
 Immune System Diseases Antibodies  >3 publications with CACB2 and Immune System Diseases
 Hypertrophy Antibodies  >2 publications with CACB2 and Hypertrophy
 Inflammation Antibodies  >2 publications with CACB2 and Inflammation
 Lung Neoplasms Antibodies  >1 publications with CACB2 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with CACB2 and Cell Transformation, Neoplastic
 Atrophy Antibodies  >1 publications with CACB2 and Atrophy
 Weight Loss Antibodies  >1 publications with CACB2 and Weight Loss

Organs/Tissues associated with CACB2 protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >30 publications with CACB2 and Heart
 Brain Antibodies  >17 publications with CACB2 and Brain
 Lung Antibodies  >6 publications with CACB2 and Lung
 Kidney Antibodies  >3 publications with CACB2 and Kidney
 Vascular Antibodies  >3 publications with CACB2 and Vascular
 Prostate Antibodies  >2 publications with CACB2 and Prostate
 Embryonic Tissue Antibodies  >2 publications with CACB2 and Embryonic Tissue
 Eye Antibodies  >1 publications with CACB2 and Eye
 Adrenal Gland Antibodies  >1 publications with CACB2 and Adrenal Gland
 Pancreas Antibodies  >1 publications with CACB2 and Pancreas
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