CLCA1 Human Protein

Name: CLCA1 Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1882956
Price: 1320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1882956

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but… More details

$1320 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CLCA1, Protein

Full Product Name

Human CLCA1 full length protein-synthetic nanodisc

Product Gene Name

CLCA1 protein

Product Synonym Names

CACC; CACC1; CLCRG1; CaCC-1; GOB5; hCLCA1; hCaCC-1

Host

HEK293

Form/Format

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Molecular Weight

100,226 Da

OMIM

603906

3D Structure

ModBase 3D Structure for A8K7I4

Tag

C-DYKDDDDK

Product Categories/Family for CLCA1 protein

Full Length Transmembrane Proteins; Ion Channels: Other

Other Notes

Small volumes of CLCA1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLCA1 purchase

MBS1882956 is a protein targeting CLCA1. Also known as Human CLCA1 full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for CLCA1. It may not necessarily be applicable to this product.

NCBI GI #

110611231

NCBI GeneID

1179

NCBI Accession #

NP_001276.2

UniProt Primary Accession #

A8K7I4

UniProt Secondary Accession #

O95151; Q5TDF4; Q9UNF6; Q9UPC6; B2RAV5

UniProt Related Accession #

A8K7I4

GenBank Nucleotide #

NM_001285.3

NCBI Official Full Name

calcium-activated chloride channel regulator 1

NCBI Official Synonym Full Names

chloride channel accessory 1

NCBI Official Symbol

CLCA1

NCBI Official Synonym Symbols

CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1

UniProt Protein Name

Calcium-activated chloride channel regulator 1

UniProt Synonym Protein Names

Calcium-activated chloride channel family member 1; hCLCA1; Calcium-activated chloride channel protein 1

Protein Family

Calcium-activated chloride channel regulator

UniProt Gene Name

CLCA1

UniProt Synonym Gene Names

CACC1; hCLCA1; CaCC-1; hCaCC-1

UniProt Entry Name

CLCA1_HUMAN

NCBI Protein Information

calcium-activated chloride channel regulator 1; calcium-dependent chloride channel-1; calcium-activated chloride channel protein 1; CLCA family member 1, chloride channel regulator; calcium-activated chloride channel family member 1; chloride channel, cal

UniProt Comments for CLCA1

CLCA1: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Belongs to the CLCR family.

Protein type: Vesicle; Channel, chloride

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular space; zymogen granule membrane; microvillus; integral to plasma membrane; plasma membrane

Molecular Function: chloride channel activity; metallopeptidase activity; metal ion binding

Biological Process: transport; calcium ion transport; chloride transport; proteolysis; transmembrane transport

Research Articles on CLCA1

1. CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CLCA1 protein

Reference Product	PubMed Publications
IL13 protein	>11 publications with CLCA1 and IL13
SERPINB2 protein	>5 publications with CLCA1 and SERPINB2
POSTN protein	>4 publications with CLCA1 and POSTN
SRC protein	>2 publications with CLCA1 and SRC
FKBP5 protein	>1 publications with CLCA1 and FKBP5
MUC5B protein	>1 publications with CLCA1 and MUC5B

Pathways associated with CLCA1 protein

Products by Pathway	Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Olfactory Transduction Pathway antibodies	Olfactory Transduction Pathway Diagram
Olfactory Transduction Pathway antibodies	Olfactory Transduction Pathway Diagram
Pancreatic Secretion Pathway antibodies	Pancreatic Secretion Pathway Diagram
Pancreatic Secretion Pathway antibodies	Pancreatic Secretion Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with CLCA1 protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>18 publications with CLCA1 and Inflammation
Neoplasms Antibodies	>9 publications with CLCA1 and Neoplasms
Disease Models, Animal Antibodies	>9 publications with CLCA1 and Disease Models, Animal
Metaplasia Antibodies	>7 publications with CLCA1 and Metaplasia
Hyperplasia Antibodies	>6 publications with CLCA1 and Hyperplasia
Carcinoma Antibodies	>5 publications with CLCA1 and Carcinoma
Neoplasms, Experimental Antibodies	>3 publications with CLCA1 and Neoplasms, Experimental
Hypertrophy Antibodies	>2 publications with CLCA1 and Hypertrophy
Lung Neoplasms Antibodies	>2 publications with CLCA1 and Lung Neoplasms
Breast Neoplasms Antibodies	>2 publications with CLCA1 and Breast Neoplasms

Organs/Tissues associated with CLCA1 protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>16 publications with CLCA1 and Intestine
Muscle Antibodies	>8 publications with CLCA1 and Muscle
Stomach Antibodies	>4 publications with CLCA1 and Stomach