CLCN6 Human Protein

Name: CLCN6 Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1883677
Price: 1205 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1883677

This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CLCN6, Protein

Full Product Name

Human CLCN6-Strep full length protein-synthetic nanodisc

Product Gene Name

CLCN6 protein

Product Synonym Names

CLC-6; CONRIBA

Host

HEK293

Form/Format

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Molecular Weight

97,289 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (11866153..11903201). Location: 1p36

OMIM

602726

3D Structure

ModBase 3D Structure for P51797

Tag

C-DYKDDDDK&Strep

Product Categories/Family for CLCN6 protein

Full Length Transmembrane Proteins; Ion Channels: Other

Other Notes

Small volumes of CLCN6 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLCN6 purchase

MBS1883677 is a protein targeting CLCN6. Also known as Human CLCN6-Strep full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for CLCN6. It may not necessarily be applicable to this product.

NCBI GI #

379698826

NCBI GeneID

1185

NCBI Accession #

NP_001243888.1

UniProt Primary Accession #

P51797

UniProt Secondary Accession #

O60818; O60819; O60820; O60821; P78520; P78521; Q17R81; Q5SNW2; A8K1T4; B4DGT7; F8W9R3

UniProt Related Accession #

P51797

GenBank Nucleotide #

NM_001256959.1

NCBI Official Full Name

chloride transport protein 6 isoform 2

NCBI Official Synonym Full Names

chloride channel, voltage-sensitive 6

NCBI Official Symbol

CLCN6

NCBI Official Synonym Symbols

CLC-6

UniProt Protein Name

Chloride transport protein 6

UniProt Synonym Protein Names

Chloride channel protein 6

Protein Family

Chloride transport protein

UniProt Gene Name

CLCN6

UniProt Synonym Gene Names

KIAA0046; ClC-6

UniProt Entry Name

CLCN6_HUMAN

NCBI Protein Information

chloride transport protein 6

UniProt Comments for CLCN6

Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.

Subcellular location: Endosome membrane; Multi-pass membrane protein. Note: Detected in detergent-resistant lipid rafts. Ref.11

Tissue specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. Ref.1 Ref.2 Ref.10

Post-translational modification: N-glycosylated on several asparagine residues. Ref.11

Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters

By similarity.

Sequence similarities: Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. [View classification]Contains 2 CBS domains.

Research Articles on CLCN6

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CLCN6 protein

Products by Pathway	Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with CLCN6 protein

Disease Name	Pubmed Publications
Seizures Antibodies	>1 publications with CLCN6 and Seizures
Congenital Abnormalities Antibodies	>1 publications with CLCN6 and Congenital Abnormalities
Fibrosis Antibodies	>1 publications with CLCN6 and Fibrosis
Heart Diseases Antibodies	>1 publications with CLCN6 and Heart Diseases
Abnormalities, Multiple Antibodies	>1 publications with CLCN6 and Abnormalities, Multiple

Organs/Tissues associated with CLCN6 protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>7 publications with CLCN6 and Blood
Brain Antibodies	>6 publications with CLCN6 and Brain
Kidney Antibodies	>4 publications with CLCN6 and Kidney
Muscle Antibodies	>3 publications with CLCN6 and Muscle
Lung Antibodies	>3 publications with CLCN6 and Lung
Embryonic Tissue Antibodies	>2 publications with CLCN6 and Embryonic Tissue
Pancreas Antibodies	>2 publications with CLCN6 and Pancreas
Testis Antibodies	>2 publications with CLCN6 and Testis
Heart Antibodies	>2 publications with CLCN6 and Heart
Eye Antibodies	>1 publications with CLCN6 and Eye