Complement C7 (C7) Human Protein

Name: C7 Protein; Complement C7; Human; MyBioSource
Brand: MyBioSource
SKU: MBS147390
Price: 395 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS147390

Introduction: C7 is necessary for formation of the membrane attack complex and is activated by bindingat the cell membrane to recently-formed C5b,C6 complexes. Each pathway of complement activation generates proteolytic enzyme complexes which bind the target… More details

$395 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complement C7, Protein

Full Product Name

Human Complement C7

Product Gene Name

C7 protein

Product Synonym Names

Complement C7 Human; Complement component C7; C7; C7 Human

Host

Human Plasma

Form/Format

C7 protein solution contains 10mM Sodium phosphate and 145mM NaCl, pH7.3.
Sterile filtered solution.

Purity/Purification

Greater than 90.0% as determined by SDS-PAGE.

Preparation and Storage

C7 Human is stable at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen below -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Molecular Weight

93,518 Da

OMIM

217070

3D Structure

ModBase 3D Structure for P10643

Human Virus Test

Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG.

Product Categories/Family for C7 protein

RECOMBINANT & NATURAL PROTEINS

Other Notes

Small volumes of C7 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C7 purchase

MBS147390 is a protein targeting C7. Also known as Human Complement C7. Host: Human Plasma.

Additional Details

NCBI/Uniprot data below describe general gene information for C7. It may not necessarily be applicable to this product.

NCBI GI #

45580688

NCBI GeneID

730

NCBI Accession #

NP_000578.2

UniProt Primary Accession #

P10643

UniProt Secondary Accession #

Q6P3T5; Q92489

UniProt Related Accession #

P10643

GenBank Nucleotide #

NM_000587.2

NCBI Official Full Name

complement component C7

NCBI Official Synonym Full Names

complement component 7

NCBI Official Symbol

UniProt Protein Name

Complement component C7

Protein Family

Complement component

UniProt Gene Name

UniProt Entry Name

CO7_HUMAN

NCBI Protein Information

complement component C7

NCBI Summary for C7

C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

UniProt Comments for C7

C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 7 Deficiency

Research Articles on C7

1. Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C7 protein

Reference Product	PubMed Publications
C8G protein	>8 publications with C7 and C8G
CLU protein	>7 publications with C7 and CLU
C8A protein	>6 publications with C7 and C8A
C8B protein	>5 publications with C7 and C8B
PLG protein	>3 publications with C7 and PLG

Pathways associated with C7 protein

Products by Pathway	Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram

Diseases associated with C7 protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>257 publications with C7 and Cardiovascular Diseases
Brain Diseases Antibodies	>209 publications with C7 and Brain Diseases
Hemolysis Antibodies	>150 publications with C7 and Hemolysis
Inflammation Antibodies	>127 publications with C7 and Inflammation
Disease Models, Animal Antibodies	>124 publications with C7 and Disease Models, Animal
Hemorrhage Antibodies	>109 publications with C7 and Hemorrhage
Necrosis Antibodies	>78 publications with C7 and Necrosis
Kidney Diseases Antibodies	>65 publications with C7 and Kidney Diseases
Lung Diseases Antibodies	>62 publications with C7 and Lung Diseases
Liver Diseases Antibodies	>44 publications with C7 and Liver Diseases

Organs/Tissues associated with C7 protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>2162 publications with C7 and Bone
Nerve Antibodies	>1027 publications with C7 and Nerve
Muscle Antibodies	>836 publications with C7 and Muscle
Brain Antibodies	>482 publications with C7 and Brain
Vascular Antibodies	>318 publications with C7 and Vascular
Liver Antibodies	>200 publications with C7 and Liver
Heart Antibodies	>192 publications with C7 and Heart
Kidney Antibodies	>163 publications with C7 and Kidney
Ganglia Antibodies	>130 publications with C7 and Ganglia
Lung Antibodies	>126 publications with C7 and Lung