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DRD1 Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS189980

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DRD1, Protein
Full Product Name
Human DRD1 full length protein-synthetic nanodisc
Product Gene Name
DRD1 protein
Product Synonym Names
DADR; DRD1A
Host
HEK293
Form/Format
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).
Molecular Weight
446
OMIM
126449
3D Structure
ModBase 3D Structure for P21728

Product Categories/Family for DRD1 protein

FLP 489; Full Length Transmembrane Proteins

Other Notes

Small volumes of DRD1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DRD1 purchase

MBS189980 is a protein targeting DRD1. Also known as Human DRD1 full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for DRD1. It may not necessarily be applicable to this product.

NCBI GI #
118228
NCBI GeneID
1812
NCBI Accession #
P21728.1
UniProt Primary Accession #
P21728
UniProt Secondary Accession #
Q4QRJ0; B2RA44
UniProt Related Accession #
P21728
NCBI Official Full Name
D(1A) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D1
NCBI Official Symbol
DRD1
NCBI Official Synonym Symbols
DADR; DRD1A
UniProt Protein Name
D(1A) dopamine receptor
UniProt Synonym Protein Names
Dopamine D1 receptor
Protein Family
D(1A) dopamine receptor
UniProt Gene Name
DRD1
UniProt Entry Name
DRD1_HUMAN
NCBI Protein Information
D(1A) dopamine receptor; D(1A) dopamine receptor; dopamine D1 receptor

UniProt Comments for DRD1

DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nucleus

Molecular Function: protein binding; dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; peristalsis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); behavioral fear response; prepulse inhibition; positive regulation of potassium ion transport; generation of action potential; thermoregulation; G-protein signaling, adenylate cyclase activating pathway; vasodilation; positive regulation of synaptic transmission, glutamatergic; adult walking behavior; dopamine metabolic process; synaptogenesis; behavioral response to cocaine; protein import into nucleus; conditioned taste aversion; positive regulation of cAMP biosynthetic process; visual learning; dopamine receptor, adenylate cyclase activating pathway; grooming behavior; response to drug; dopamine transport; dentate gyrus development; cerebral cortex GABAergic interneuron migration; striatum development; maternal behavior; response to amphetamine; adenylate cyclase activation; regulation of dopamine metabolic process; mating behavior; regulation of dopamine uptake; transmission of nerve impulse; astrocyte development; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; habituation; glucose import; operant conditioning; sensitization; positive regulation of release of sequestered calcium ion into cytosol; dopamine receptor, phospholipase C activating pathway; positive regulation of cell migration
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Research Articles on DRD1

1. Constitutive D1R differs from D5R in that it fails to drive expression CRE-regulated genes. Treatment of a D1R line with cis-flupentixol induced up-regulation of Na,K-ATPase-alpha2, NHE-2 and NHE-3 mRNA levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DRD1 protein

 Reference Product  PubMed Publications
 ADORA2A protein  >2 publications with DRD1 and ADORA2A
 GNAS protein  >1 publications with DRD1 and GNAS

Pathways associated with DRD1 protein

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram

Diseases associated with DRD1 protein

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >110 publications with DRD1 and Mental Disorders
 Schizophrenia Antibodies  >47 publications with DRD1 and Schizophrenia
 Nervous System Diseases Antibodies  >34 publications with DRD1 and Nervous System Diseases
 Bipolar Disorder Antibodies  >21 publications with DRD1 and Bipolar Disorder
 Movement Disorders Antibodies  >15 publications with DRD1 and Movement Disorders
 Hypertension Antibodies  >12 publications with DRD1 and Hypertension
 Depressive Disorder Antibodies  >11 publications with DRD1 and Depressive Disorder
 Basal Ganglia Diseases Antibodies  >10 publications with DRD1 and Basal Ganglia Diseases
 Dyskinesias Antibodies  >8 publications with DRD1 and Dyskinesias
 Psychotic Disorders Antibodies  >7 publications with DRD1 and Psychotic Disorders

Organs/Tissues associated with DRD1 protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >98 publications with DRD1 and Brain
 Eye Antibodies  >2 publications with DRD1 and Eye
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