GRM4 Human Protein

Name: GRM4 Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1880076
Price: 1320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1880076

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in… More details

$1320 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GRM4, Protein

Full Product Name

Human GRM4 full length protein-synthetic nanodisc

Product Gene Name

GRM4 protein

Product Synonym Names

GPRC1D; MGLUR4; mGlu4

Host

HEK293

Form/Format

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).

Molecular Weight

101,868 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (33989623..34123399, complement). Location: 6p21.3

OMIM

604100

3D Structure

ModBase 3D Structure for Q14833

Product Categories/Family for GRM4 protein

FLP 489; Full Length Transmembrane Proteins

Other Notes

Small volumes of GRM4 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRM4 purchase

MBS1880076 is a protein targeting GRM4. Also known as Human GRM4 full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for GRM4. It may not necessarily be applicable to this product.

NCBI GI #

4504141

NCBI GeneID

2914

NCBI Accession #

NP_000832.1

UniProt Primary Accession #

Q14833

UniProt Secondary Accession #

Q5SZ84; B7Z1T9; B7Z1U6; F5GXM5

UniProt Related Accession #

Q14833; AAB34891

GenBank Nucleotide #

NM_000841.2

NCBI Official Full Name

metabotropic glutamate receptor 4 isoform 1

NCBI Official Synonym Full Names

glutamate receptor, metabotropic 4

NCBI Official Symbol

GRM4

NCBI Official Synonym Symbols

mGlu4; GPRC1D; MGLUR4

UniProt Protein Name

Metabotropic glutamate receptor 4

Protein Family

Metabotropic glutamate receptor

UniProt Gene Name

GRM4

UniProt Synonym Gene Names

GPRC1D; MGLUR4; mGluR4

UniProt Entry Name

GRM4_HUMAN

NCBI Protein Information

metabotropic glutamate receptor 4

UniProt Comments for GRM4

mGluR4: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Protein type: Cell development/differentiation; GPCR, family 3; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane; terminal button; presynaptic active zone membrane; intracellular; cytoplasmic vesicle; dendritic shaft

Molecular Function: G-protein coupled receptor activity; calmodulin binding; group III metabotropic glutamate receptor activity; glutamate receptor activity; calcium-dependent protein binding

Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; positive regulation of MAPKKK cascade; activation of MAPK activity; neurotransmitter secretion; regulation of neuron apoptosis; learning; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

Research Articles on GRM4

1. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GRM4 protein

Products by Pathway	Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies	GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram
Taste Transduction Pathway antibodies	Taste Transduction Pathway Diagram

Diseases associated with GRM4 protein

Disease Name	Pubmed Publications
Epilepsy Antibodies	>3 publications with GRM4 and Epilepsy
Brain Diseases Antibodies	>3 publications with GRM4 and Brain Diseases
Nervous System Diseases Antibodies	>3 publications with GRM4 and Nervous System Diseases
Epilepsies, Myoclonic Antibodies	>2 publications with GRM4 and Epilepsies, Myoclonic
Developmental Disabilities Antibodies	>1 publications with GRM4 and Developmental Disabilities
Learning Disorders Antibodies	>1 publications with GRM4 and Learning Disorders

Organs/Tissues associated with GRM4 protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with GRM4 and Brain